Inhibition of P. gingivalis infection by the SLPI from gingival epithelial cells

牙龈上皮细胞的 SLPI 抑制牙龈卟啉单胞菌感染

• 批准号: 21592340
• 负责人: KIMURA Shigenobu
• 金额: $ 3万
• 依托单位: Iwate Medical University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2009
• 资助国家: 日本
• 起止时间: 2009 至 2011
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-21592340/
• 关键词: SLPI; 歯肉上皮細胞; P. gingivalis; 感染抑制; P.gingivalis

The results indicated that gingival epithelial cells could be a substantial producer of secretory leukocyte protease inhibitor(SLPI) that functions inhibitory to the pathogenic Porphyromonas gingivalis protease in gingival crevices. It was also suggested that the SLPI production could increase in response to P. gingivalis through the stimulation with its pathogenic constituents.

结果表明，牙龈上皮细胞可能是分泌型白细胞蛋白酶抑制剂（SLPI）的主要生产者，其功能是抑制牙龈卟啉单胞菌在龈沟中的致病性蛋白酶。同时也表明，牙龈卟啉单胞菌通过其致病成分的刺激，可以增加SLPI的产生。

项目成果

Relationship of quantitative salivary levels of Streptococcus mutans and S-sobrinus in mothers to caries status and colonization of mutans streptococci in plaque in their 2.5-year-old children

• DOI: 10.1111/j.1600-0528.2009.00472.x
• 发表时间: 2009-06-01
• 期刊: COMMUNITY DENTISTRY AND ORAL EPIDEMIOLOGY
• 影响因子: 2.3
• 作者: Kishi, M.;Abe, A.;Yonemitsu, M.
• 通讯作者: Yonemitsu, M.

Auto-catalytic propeptide processing facilitates the final hetero-catalytic maturation of glutamyl endopeptidase GluV8

自催化前肽加工促进谷氨酰内肽酶 GluV8 最终异质催化成熟

• 发表时间: 2011
• 作者: Ohara-Nemoto;Y.;Rouf;S.M.A.;Shimoyama;Y.;Kimura;S.;Ono;T. and Nemoto;T.K
• 通讯作者: T.K

Porphyromonas gingivalis DPP11の酵素活性とAsp/Glu特異性を規定するArg670

Arg670 定义了牙龈卟啉单胞菌 DPP11 的酶活性和 Asp/Glu 特异性

• 发表时间: 2011
• 作者: 根本孝幸;小野俊雄;下山佑;木村重信;根本優子
• 通讯作者: 根本優子

Prediction of colonization of periodontopathogens in plaque by VSC measurement.

通过 VSC 测量预测牙菌斑中牙周病原体的定植。

• 发表时间: 2010
• 作者: Kishi;M.;Ohara-Nemoto;Y.;Kimura;S.;Aizawa;F.;Kishi;K.;Takahashi;M.;Yonemitsu;M.
• 通讯作者: M.

Prediction of colonization of periodontopathogens in plaque by VSC measurement

通过 VSC 测量预测牙菌斑中牙周病原体的定植

• 发表时间: 2010
• 作者: Kishi;M.;Ohara-Nemoto;Y.;Kimura;S.;Aizawa;F.;Kishi;K.;Takahashi;M. and Yonemitsu;M.
• 通讯作者: M.