FGF signaling accelerate epithelial regeneration by Oral Epithelial Stem Cells

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Fibroblast growth factor-10(FGF-10) is a known epithelial mitogen in several organ systems, such as the lung, that acts in a bidirectional paracrine manner and acts exclusively through a subset of receptors such as FGFr2b. However, its role in oral epithelial regeneration is unknown. We investigated the role of FGFr2b/FGF-10 signaling in oral epithelial wound healing using FGF-10 overexpression(OE) and FGFr2b attenuation/knock-down(KD) transgenic mice. The present results suggested that, 1) Under-developing of the epithelial layer was noted in the FGFr2b KD mice, whereas over-developing was noted in the FGF-10 OE mice. 2) FGF10 overexpression initiated the parakeratosis of oral epithelium or urothelium and 3) FGF10 overexpression worked the proliferation of the basal laminae in the stratified squamous epithelium and transitional epithelium. Form these results, FGF-10/FGFr2b signaling appears to play an active proliferation in Oral Epithelial Stem Cells, and accelerate the regenerative capacity of the oral epithelium.