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Analyses and applications of novel mechanism of phospho-independent regulation of lipid metabolism by Trypanosoma brucei 14-3-3

Analyses and applications of novel mechanism of phospho-independent regulation of lipid metabolism by Trypanosoma brucei 14-3-3
布氏锥虫14-3-3磷酸非依赖性脂质代谢调节新机制的分析与应用
批准号:
20590434
负责人:
INOUE Masahiro
金额:
$3.08万
依托单位:
依托单位国家:
日本
项目类别:
Grant-in-Aid for Scientific Research (C)
财政年份:
2008
资助国家:
日本
项目状态:
已结题
起止时间:
2008 至 2010

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中文摘要
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英文摘要
Trypanosoma brucei is a causative agent of sleeping sickness. More than 30,000 infected patients died of this devastating disease. One of the aims for this research is to identify the molecular mechanisms by which T. brucei 14-3-3s control the motility, cytokinesis, and cell cycle focusing on the lipid metabolism controlled by Tb14-3-3s as we discovered. We found that Tb14-3-3s interact with the enzymes involved in sugar or lipid metabolism, and protein kinases. One of the protein kinases among them is found out to be critical for the regulation of the motility, cytokinesis and cell cycle.
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Oxidative Stress Plays a Criticaal Role in Inactivating Mutant BRAF by Geldanamycin Derivatives.
氧化应激在格尔德霉素衍生物灭活突变体 BRAF 中发挥着关键作用。
DOI: --
发表时间: 2008
期刊: Cancer Res 68
影响因子: --
作者: [Y. Fukuyo, M. Inoue, T. Nakajima, et al.]
通讯作者: et al.
Biological significance of heterodimeric form of Trypanosoma brucei 14-3-3 I and II
布氏锥虫 14-3-3 I 和 II 异二聚体形式的生物学意义
DOI: --
发表时间: 2009
期刊:
影响因子: --
作者: [井上雅広, 他]
通讯作者:
DOI: 10.1371/journal.pone.0015566
发表时间: 2010-12-21
期刊: PLOS ONE
影响因子: 3.7
作者: [Inoue, Masahiro, Yasuda, Kouichi, Fukuma, Toshihide]
通讯作者: Fukuma, Toshihide
DOI: 10.1093/jb/mvp156
发表时间: 2010-02-01
期刊: JOURNAL OF BIOCHEMISTRY
影响因子: 2.7
作者: [Ismail, Nor Ismaliza Mohd, Yuasa, Tsuyoshi, Tsuji, Akihiko]
通讯作者: Tsuji, Akihiko
13
    Roe of polarity switching of cancer cell clusters in metastasis
    • 批准号:
      18H02648
    • 项目类别:
      Grant-in-Aid for Scientific Research (B)
    • 资助金额:
      $10.98万
    • 财政年份:
      2018
    • 负责人:
      INOUE Masahiro
    • 依托单位:
    Malignant conversion of cancer cells by disruption and remodeling of cancer cell-clusters in newly developed primary culture system
    Identification and characterization of novel kinase, AKB14-3-3-1, which is a possible target of sleeping sickness.
    • 批准号:
      23590500
    • 项目类别:
      Grant-in-Aid for Scientific Research (C)
    • 资助金额:
      $3.33万
    • 财政年份:
      2011
    • 负责人:
      INOUE Masahiro
    • 依托单位:
    Development of Stretchable Conductive Inks for Advanced Human/machine Interfaces
    海外基金