Clarify the mechanism of reduction in the secretion of saliva on chronic sympathetic stimulation and these applications to human sensing

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We generated experimental system to clarify the mechanism of reduction in the secretion of saliva on chronic stress by administration of phenylephrine(α1 adrenergic receptor agonist) to mice. The salivary kallikrein activity in the PHE was significantly lower than that in the CTL. However analysis by proteomic suggested that amount of mk22 and Ren2 was decreased in the PHE, there was no significant difference in the expression of mRNA. On the other hand, the phosphorylation of ERK1/2 was increased in parotid gland, whereas it was decreased in submandibular gland. These results can be attributed to decrease of elevation of intracellular Ca^<2+>.