Clarification of dorsal root evoked synaptic responses in lamina I neurons

细胞内记录来自中央管附近的局灶性刺激诱发的逆行动作电位所识别的I层神经元。刺激背根可在大多数神经元中诱发快速EPSP，而重复刺激可在20%的I板层神经元中诱发慢EPSP。后者能被P物质去极化，并被NK1受体拮抗剂拮抗，提示I板层神经元接受含有C传入纤维的P物质，P物质能调节I板层的伤害性传递。

Intracellular recordings were made from lamina I neurons which were identified by antidromic action potentials evoked by focal stimulation near the central canal. Stimulation of the dorsal root elicited a fast EPSP in the majority of neurons and repetitive stimulation evoked a slow EPSP in 20% of lamina I neurons. The latter neurons were depolarized by application of substance P and antagonized by a NK1 receptor antagonist, suggesting that the lamina I neurons receive substance P containing C afferent fibers which could modulate the nociceptive transmission in the lamina I.