Clarification of dorsal root evoked synaptic responses in lamina I neurons

细胞内记录从I层神经元，其中确定了由中央管附近的局灶刺激诱发的逆行动作电位。电刺激背根可使大多数神经元产生快EPSP，而重复电刺激可使20%的第一层神经元产生慢EPSP。后一种神经元被P物质去极化并被NK1受体拮抗剂拮抗，提示I层神经元接受含P物质的C传入纤维，后者可调节I层的伤害性信息传递。

Intracellular recordings were made from lamina I neurons which were identified by antidromic action potentials evoked by focal stimulation near the central canal. Stimulation of the dorsal root elicited a fast EPSP in the majority of neurons and repetitive stimulation evoked a slow EPSP in 20% of lamina I neurons. The latter neurons were depolarized by application of substance P and antagonized by a NK1 receptor antagonist, suggesting that the lamina I neurons receive substance P containing C afferent fibers which could modulate the nociceptive transmission in the lamina I.