A novel approach to treat severe trauma using gene introduction by nanomicelle into skeletal muscle
A novel approach to treat severe trauma using gene introduction by nanomicelle into skeletal muscle
批准号:
21300177
负责人:
ITAKA Keiji
金额:
$11.9万
依托单位:
依托单位国家:
日本
项目类别:
Grant-in-Aid for Scientific Research (B)
财政年份:
2009
资助国家:
日本
项目状态:
已结题
起止时间:
2009 至 2011
中文摘要
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英文摘要
Polyplex nanomicelle is an effective and biocompatible gene carrier. By hydrodynamic injection of nanomicelle into skeletal muscle of mice, a prolonged transgene expression was obtained for more than a month. The addition of chondroitin sulfate to the nanomicelle further reduced the tissue damage in the muscle. In model mice of peripheral nerve injury, the introduction of IGF-1 gene into the muscle using the nanomicelle accelerated the recovery of motor function and sensation of the paralyzed limb, through the processes of the muscular hypertrophy induced by IGF-1. This strategy is promising for avoiding disuse atrophy and the eventual early recovery of motor and sensory functions after severe trauma.
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生分解性ナノミセルによる遺伝子デリバリーと機能評価
使用可生物降解的纳米胶束进行基因传递和功能评估
DOI:
--
发表时间:
2009
期刊:
影响因子:
--
作者:
[K. Yoshinori, K. Iramina, 位高啓史,石井武彦,片岡一則]
通讯作者:
位高啓史,石井武彦,片岡一則
細胞をターゲットするドラッグ・遺伝子デリバリーシステムの研究展開
针对细胞的药物/基因递送系统的研究和开发
DOI:
--
发表时间:
2009
期刊:
影响因子:
--
作者:
[紙谷浩之, 内山雅普, Jingshu Piao, 中津可道, 續輝久, 原島秀吉, Y. Yasui, 位高啓史]
通讯作者:
位高啓史
Biocompatible Polyplex Nanomicelle for Safe and Effective Gene Transfer
生物相容性 Polyplex 纳米胶束可实现安全有效的基因转移
DOI:
--
发表时间:
2010
期刊:
影响因子:
--
作者:
[T.Hayami, et al., Itaka K]
通讯作者:
Itaka K
DOI:
10.1016/j.jconrel.2009.12.014
发表时间:
2010-04-02
期刊:
JOURNAL OF CONTROLLED RELEASE
影响因子:
10.8
作者:
[Itaka, Keiji, Osada, Kensuke, Kataoka, Kazunori]
通讯作者:
Kataoka, Kazunori
生分解性カチオニックポリマーによる遺伝子デリバリー
使用可生物降解的阳离子聚合物进行基因递送
DOI:
--
发表时间:
2009
期刊:
影响因子:
--
作者:
[Kazuhiko Ishihara, Yusuke Goto, Ryosuke Matsuno, Tomohiro Konno, Madoka Takai, 山本玲子, 位高啓史,石井武彦,片岡一則]
通讯作者:
位高啓史,石井武彦,片岡一則
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mRNA medicine for neuroprotection after cerebral ischemic attack
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批准号:16K15642
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Development of mRNA medicine for treatment of neural diseases and injury
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Development of in vivo mRNA delivery system for treating diseases
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财政年份:2012
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Gene therapy for achodroplasia using a biocompatible non-viral gene delivery system
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批准号:23659708
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项目类别:Grant-in-Aid for Challenging Exploratory Research
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资助金额:$2.33万
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财政年份:2011
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负责人:ITAKA Keiji
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依托单位:
Development of multi-functional nanocarrier of siDNA and application for bone and joint diseases
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批准号:17390412
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项目类别:Grant-in-Aid for Scientific Research (B)
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资助金额:$10.55万
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财政年份:2005
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负责人:ITAKA Keiji
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依托单位:
海外基金