A novel approach to treat severe trauma using gene introduction by nanomicelle into skeletal muscle

点击翻译按钮获取中文摘要

Polyplex nanomicelle is an effective and biocompatible gene carrier. By hydrodynamic injection of nanomicelle into skeletal muscle of mice, a prolonged transgene expression was obtained for more than a month. The addition of chondroitin sulfate to the nanomicelle further reduced the tissue damage in the muscle. In model mice of peripheral nerve injury, the introduction of IGF-1 gene into the muscle using the nanomicelle accelerated the recovery of motor function and sensation of the paralyzed limb, through the processes of the muscular hypertrophy induced by IGF-1. This strategy is promising for avoiding disuse atrophy and the eventual early recovery of motor and sensory functions after severe trauma.