Modification for immunological function via Toll-like receptors in macrophages due to physical exercise

运动训练可阻止炎性巨噬细胞向脂肪组织的渗透，对肥胖相关的慢性炎症有抗炎作用。高脂饮食增加了腹膜巨噬细胞Toll样受体2的表达，并增强了全身炎症。另一方面，运动训练增强了Ghrelin的表达，Ghrelin在腹膜巨噬细胞中发挥着强大的抗炎作用，这表明运动训练通过Ghrelin抑制高脂饮食诱导的炎症。

Exercise training prevented the infiltration of inflammatory macrophages to adipose tissue and exerted anti-inflammatory effects for obesity-related chronic inflammation. A high fat diet increased Toll-like receptor 2 expression in peritoneal macrophages and enhanced systemic inflammation. On the other hand, exercise training enhanced expression of ghrelin, which exerts potent anti-inflammatory effects in peritoneal macrophages, suggesting that exercise training suppresses a high fat diet-induced inflammation through ghrelin.