Study on the Structures, Functions and Applications of Sphingolipid-metabolizing machinery

鞘脂代谢机制的结构、功能及应用研究

基本信息

  • 批准号:
    21380066
  • 负责人:
  • 金额:
    $ 11.9万
  • 依托单位:
  • 依托单位国家:
    日本
  • 项目类别:
    Grant-in-Aid for Scientific Research (B)
  • 财政年份:
    2009
  • 资助国家:
    日本
  • 起止时间:
    2009 至 2011
  • 项目状态:
    已结题

项目摘要

In this study, we explored the structures and functions of novel sphingolipid-metabolizing enzymes(ceramidase, sphingolipid ceramide N-deacylase, Hex1, NgaP, EGCrP1, EGALC), which had been identified and cloned in our laboratory. Interestingly, both ceramidase and sphingolipid ceramide N-deacylase are a zinc-dependent amidohydrolase. The cleavage of N-acyl linkage of ceramide by ceramidase follows a similar mechanism as observed for the zinc-dependent carboxypeptidases. Hex1 and NgaP were found to cleave the terminal
本研究对本实验室已鉴定和克隆的新型鞘脂代谢酶(神经酰胺酶、鞘脂神经酰胺N-脱酰酶、Hex 1、NgaP、EGCrP 1、EGALC)的结构和功能进行了研究。有趣的是,神经酰胺酶和鞘脂神经酰胺N-脱酰酶都是锌依赖性酰胺水解酶。神经酰胺酶对神经酰胺的N-酰基键的裂解遵循与锌依赖性羧肽酶所观察到的类似的机制。发现Hex 1和NgaP切割末端

项目成果

期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
Lack of lacto/neolacto-glycolipids enhances the formation of glycolipid-enriched microdomains, facilitating B cell activation
Structure and functions of sphingolipid-metabolizing machinery
鞘脂代谢机制的结构和功能
  • DOI:
  • 发表时间:
    2010
  • 期刊:
  • 影响因子:
    0
  • 作者:
    掛川苑美;鈴木秀之;M.Ito
  • 通讯作者:
    M.Ito
セタミド:基礎戸応用(セラミドの代謝)
乙酰胺:基本应用(神经酰胺代谢)
  • DOI:
  • 发表时间:
  • 期刊:
  • 影响因子:
    0
  • 作者:
  • 通讯作者:
Qualitative and quantitative cellular glycomics of glycosphingolipids based on rhodococcal endoglycoceramidase-assisted glycan cleavage, glycoblotting-assisted sample preparation, and matrix-assisted laser desorption ionization tandem time-of-flight mass
基于红球菌内切糖神经酰胺酶辅助聚糖裂解、糖印迹辅助样品制备和基质辅助激光解吸电离串联飞行时间质量的鞘糖脂的定性和定量细胞糖组学
  • DOI:
  • 发表时间:
    2011
  • 期刊:
  • 影响因子:
    0
  • 作者:
    Fujitani N;Ito M(9人中8番目)
  • 通讯作者:
    Ito M(9人中8番目)
Biological significance of non-lysososmal degradation of glucosylceramide
葡萄糖神经酰胺非溶酶体降解的生物学意义
  • DOI:
  • 发表时间:
    2011
  • 期刊:
  • 影响因子:
    0
  • 作者:
    Wu;T.;Ni;Y.;Kato;H. and Fu;Z;Ito M
  • 通讯作者:
    Ito M
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ITO Makoto其他文献

Proposal of a computational modelling method of curved origami structures based on finite element analysis models with truss elements for creases modelling
基于折痕建模桁架单元有限元分析模型的弯曲折纸结构计算建模方法的提出

ITO Makoto的其他文献

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{{ truncateString('ITO Makoto', 18)}}的其他基金

Studies on structures and functions of fungus glycolipid-metabolizing enzymes
真菌糖脂代谢酶的结构与功能研究
  • 批准号:
    24380058
  • 财政年份:
    2012
  • 资助金额:
    $ 11.9万
  • 项目类别:
    Grant-in-Aid for Scientific Research (B)
Changes of developments of central auditory system following early hearing loss in animal experiment.
动物实验中早期听力损失后中枢听觉系统发育的变化。
  • 批准号:
    22591877
  • 财政年份:
    2010
  • 资助金额:
    $ 11.9万
  • 项目类别:
    Grant-in-Aid for Scientific Research (C)
Modeling of sediment-wave depositional facies
沉积波沉积相模拟
  • 批准号:
    22540465
  • 财政年份:
    2010
  • 资助金额:
    $ 11.9万
  • 项目类别:
    Grant-in-Aid for Scientific Research (C)
Human Flow and the reintegration of return migrants in South East Asia:Social Anthropological perspective
东南亚人口流动与回返移民的重新融入:社会人类学视角
  • 批准号:
    22320175
  • 财政年份:
    2010
  • 资助金额:
    $ 11.9万
  • 项目类别:
    Grant-in-Aid for Scientific Research (B)
Coexistence phenomena of chemical-bonding-like structures in neutron excess systems
中子过剩体系中类化学键结构的共存现象
  • 批准号:
    21740211
  • 财政年份:
    2009
  • 资助金额:
    $ 11.9万
  • 项目类别:
    Grant-in-Aid for Young Scientists (B)
Evaluation of Efficacy and Long-term Results of Catheter Ablation in Drug-refractory Atrial Fibrillation
药物难治性心房颤动导管消融的疗效和长期结果评价
  • 批准号:
    21590891
  • 财政年份:
    2009
  • 资助金额:
    $ 11.9万
  • 项目类别:
    Grant-in-Aid for Scientific Research (C)
SOCIAL ANTHROPOLOGICAL STUDY FOR ORGANIZING SAFETY NETWORKS OF THE ELDERLY IN EAST ASIA
东亚老年人安全网络组织的社会人类学研究
  • 批准号:
    19320139
  • 财政年份:
    2007
  • 资助金额:
    $ 11.9万
  • 项目类别:
    Grant-in-Aid for Scientific Research (B)
Study on structures, functions and applications of novel endo-type and exo-type glycoceramidases involved in glycosphingolipid metabolism
鞘糖脂代谢中新型内切型和外切型神经酰胺酶的结构、功能及应用研究
  • 批准号:
    19380061
  • 财政年份:
    2007
  • 资助金额:
    $ 11.9万
  • 项目类别:
    Grant-in-Aid for Scientific Research (B)
Development of central auditory systemand and plasticity of inner ear in congenital deaf model rat
先天性聋模型大鼠中枢听觉系统发育及内耳可塑性
  • 批准号:
    19591961
  • 财政年份:
    2007
  • 资助金额:
    $ 11.9万
  • 项目类别:
    Grant-in-Aid for Scientific Research (C)
Unified studies of molecular structures and reaction mechanism In light neutron-excess systems
轻中子过剩体系中分子结构和反应机理的统一研究
  • 批准号:
    18740129
  • 财政年份:
    2006
  • 资助金额:
    $ 11.9万
  • 项目类别:
    Grant-in-Aid for Young Scientists (B)

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Development of novel platform for enzyme utilization in the body based on polymeric nanocapsules
基于聚合物纳米胶囊的体内酶利用新平台的开发
  • 批准号:
    26288082
  • 财政年份:
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