Study on the Structures, Functions and Applications of Sphingolipid-metabolizing machinery
Study on the Structures, Functions and Applications of Sphingolipid-metabolizing machinery
批准号:
21380066
负责人:
ITO Makoto
金额:
$11.9万
依托单位:
依托单位国家:
日本
项目类别:
Grant-in-Aid for Scientific Research (B)
财政年份:
2009
资助国家:
日本
项目状态:
已结题
起止时间:
2009 至 2011
中文摘要
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英文摘要
In this study, we explored the structures and functions of novel sphingolipid-metabolizing enzymes(ceramidase, sphingolipid ceramide N-deacylase, Hex1, NgaP, EGCrP1, EGALC), which had been identified and cloned in our laboratory. Interestingly, both ceramidase and sphingolipid ceramide N-deacylase are a zinc-dependent amidohydrolase. The cleavage of N-acyl linkage of ceramide by ceramidase follows a similar mechanism as observed for the zinc-dependent carboxypeptidases. Hex1 and NgaP were found to cleave the terminal
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DOI:
10.1073/pnas.0914298107
发表时间:
2010-06-29
期刊:
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
影响因子:
11.1
作者:
[Togayachi, Akira, Kozono, Yuko, Narimatsu, Hisashi]
通讯作者:
Narimatsu, Hisashi
Qualitative and quantitative cellular glycomics of glycosphingolipids based on rhodococcal endoglycoceramidase-assisted glycan cleavage, glycoblotting-assisted sample preparation, and matrix-assisted laser desorption ionization tandem time-of-flight mass
基于红球菌内切糖神经酰胺酶辅助聚糖裂解、糖印迹辅助样品制备和基质辅助激光解吸电离串联飞行时间质量的鞘糖脂的定性和定量细胞糖组学
DOI:
--
发表时间:
2011
期刊:
J. Biol. Chem
影响因子:
--
作者:
[Fujitani N, Ito M(9人中8番目)]
通讯作者:
Ito M(9人中8番目)
DOI:
--
发表时间:
2010
期刊:
影响因子:
--
作者:
[掛川苑美, 鈴木秀之, M.Ito]
通讯作者:
M.Ito
セタミド:基礎戸応用(セラミドの代謝)
乙酰胺:基本应用(神经酰胺代谢)
DOI:
--
发表时间:
期刊:
影响因子:
--
作者:
[]
通讯作者:
Biological significance of non-lysososmal degradation of glucosylceramide
葡萄糖神经酰胺非溶酶体降解的生物学意义
DOI:
--
发表时间:
2011
期刊:
影响因子:
--
作者:
[Wu, T., Ni, Y., Kato, H. and Fu, Z, Ito M]
通讯作者:
Ito M
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