Visulization of Wnt/Notch signaling for the maintenance of mesenchymal stem cells

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It has been advocated that Wnt, Notch signals involve molecular mechanism of self-renewal or differentiation in various somatic stem cells. In mammalian development, stem cell controls complicated organizational structure as high-order function, while controlling self-renew and differentiation. In this project, we attempted to clarify self-renewal and cell lineage decision mechanism of MSC. Our method was to visualize Wnt, Notch signals, which has a potential for temporospatial controls of stem cells. By visualizing Wnt, Notch signals, we could analyze how Wnt/Notch separates their roles, or interacts with other molecules in order for self-replication.