Activity-dependent regulation of spine morphology by RICS/PX-RICS

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Postsynaptic protein RICS is thought to serve as a link between excitatory signaling and synaptic adhesion. In this research project, we showed that, by using hippocampal neurons of RICS knockout mice, RICS functions downstream of NMDA/CaMKII signaling and upstream of Cdc42/JNK signaling. We also demonstrated that PX-RICS, a splicing variant of RICS, is localized to the spine apparatus together with its cargos(N-cadherin,β-catenin), linkers(GABARAP, 14-3-3) and motors(dynein, dynactin). These findings suggest that PX-RICS-dependent trafficking system works in dendrites and/or dendritic spines.