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Molecular mechanism of tumor cell growth

Molecular mechanism of tumor cell growth
肿瘤细胞生长的分子机制
批准号:
17014011
负责人:
AKIYAMA Tetsu
金额:
$248.06万
依托单位:
依托单位国家:
日本
项目类别:
Grant-in-Aid for Scientific Research on Priority Areas
财政年份:
2005
资助国家:
日本
项目状态:
已结题
起止时间:
2005 至 2009

项目摘要

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中文摘要
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英文摘要
We identified D8 as a p53 target gene and found that D8 is involved in genome stress-induced apoptotic cell death. We also identified Asef and Asef2, guanine nucleotide exchange factors that are activated by the tumor suppressor APC, and found that they are critically involved in intestinal adenoma formation and tumor progression and may be promising molecular targets for therapy of colorectal tumors.
期刊论文(78)
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会议论文
PX-RICS mediates ER-to-Golgi transport of the N-cadherin/β-catenin complex
PX-RICS 介导 N-钙粘蛋白/β-连环蛋白复合物的 ER 至高尔基体转运
DOI: --
发表时间: 2008
期刊: Genes Dev. 22
影响因子: --
作者: [Nakamura T., Hayashi T., Nasu-Nishimura Y., Sakaue F., Okabe T., Ohwada S., Matsuura K., Akiyama T., Haraguchi K., Nakamura T.]
通讯作者: Nakamura T.
Phosphorylation and activation of a Racl/Cdc42 guanine nucleotide exchange factor Asef in A431 cells stimulated by epidermal growth factor
表皮生长因子刺激的 A431 细胞中 Racl/Cdc42 鸟嘌呤核苷酸交换因子 Asef 的磷酸化和激活
DOI: --
发表时间: 2008
期刊: J Cell Sci. 121
影响因子: --
作者: [Itoh, R.]
通讯作者: R.
Novel clusters of highly expressed genes accompany genomic amplification in breast cancers.
新的高表达基因簇伴随着乳腺癌的基因组扩增。
DOI: --
发表时间: 2007
期刊: FEBS Letters 581
影响因子: --
作者: [Murata-Kamiya, N., Kawasaki Y., Shibata H., Ito E.]
通讯作者: Ito E.
Requirement of the tumor suppressor APC for the clustering of PSD-95 and AMPA receptors in hippocampal neurons.
海马神经元中 PSD-95 和 AMPA 受体聚集需要肿瘤抑制 APC。
DOI: --
发表时间: 2007
期刊: Eur. J. Neurosci 26
影响因子: --
作者: [Murata-Kamiya, N., Kawasaki Y., Shibata H., Ito E., Shimomura A.]
通讯作者: Shimomura A.
66
    The analysis for molecular mechanism of lifespan regulation by RNA binding protein
    • 批准号:
      25670138
    • 项目类别:
      Grant-in-Aid for Challenging Exploratory Research
    • 资助金额:
      $2.5万
    • 财政年份:
      2013
    • 负责人:
      AKIYAMA Tetsu
    • 依托单位:
    Activity-dependent regulation of spine morphology by RICS/PX-RICS
    • 批准号:
      21390075
    • 项目类别:
      Grant-in-Aid for Scientific Research (B)
    • 资助金额:
      $11.9万
    • 财政年份:
      2009
    • 负责人:
      AKIYAMA Tetsu
    • 依托单位:
    The Dlg signal transduction pathway
    • 批准号:
      19390082
    • 项目类别:
      Grant-in-Aid for Scientific Research (B)
    • 资助金额:
      $3.16万
    • 财政年份:
      2007
    • 负责人:
      AKIYAMA Tetsu
    • 依托单位:
    Molecular mechanism of apotosis induced by a novel RNA-binding protein D8
    • 批准号:
      17390089
    • 项目类别:
      Grant-in-Aid for Scientific Research (B)
    • 资助金额:
      $9.41万
    • 财政年份:
      2005
    • 负责人:
      AKIYAMA Tetsu
    • 依托单位:
    海外基金