通过微环境重建和转录因子及其网络分析阐明免疫反应调节的分子机制-猫眼课题宝

通过微环境重建和转录因子及其网络分析阐明免疫反应调节的分子机制

批准号：

21390077

负责人：

SHIMIZU Akira

金额：

$11.73万

依托单位：

Kyoto University

依托单位国家：

日本

项目类别：

Grant-in-Aid for Scientific Research (B)

财政年份：

2009

资助国家：

日本

项目状态：

已结题

起止时间：

2009-04-01 至 2013-03-31

来源：

https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-21390077/

关键词：

分子免疫学免疫制御転写因子遺伝子組換え抗体遺伝子発現制御免疫学遺伝子腸管免疫制御性T細胞 IgA Runx retinoic acid TGF-β1 自己免疫炎症クラススイッチ

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中文摘要

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英文摘要

It is essential for proper for proper progression of immune reaction that construction of specific microenvironment and harmonized function of a variety of immuno-competent cells. It is tried to elucidate molecular mechanisms of such immune reaction by reconstruction of such microenvironment in vitro and analyses of transcription factors and their networks regulated by such microenvironment.An in vitro culture system that very efficiently induces class switching to IgA was established. It was found that Runx transcription factors are essential for IgA class switching and they act downstream of signals from retinoic acid TGF-beta1, and that Runx3 is essential for differentiation and maturation of regulatory T cells.

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期刊：

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Journal of translational medicine

影响因子： 7.4

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[Ido A, Moriuchi A, Numata M, Murayama T, Teramukai S, Marusawa H, Yamaji N, Setoyama H, Kim ID, Chiba T, Higuchi S, Yokode M, Fukushima M, Shimizu A, Tsubouchi H]

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DOI： 10.4049/jimmunol.1000848

发表时间： 2010-08-15

期刊：

JOURNAL OF IMMUNOLOGY

影响因子： 4.4

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DOI： 10.1093/intimm/dxp014

发表时间： 2009-04

期刊：

International immunology

影响因子： 4.4

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DOI： --

发表时间： 2012

期刊：

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影响因子： 4.1

作者：

[Sakata-Goto, T., Takahashi, K., Kiso, H., Huang, B., Tsukamoto, H., Takemoto, M., Hayashi, T., Sugai, M., Nakamura, T., Yokota, Y., Shimizu, A., Slavkin, H., Bessho, K.]

通讯作者： K.