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Search for methods to control and treat allergy by regulating class switch recombination

寻找通过调节类别转换重组来控制和治疗过敏的方法

基本信息

批准号：
24659147
负责人：
SHIMIZU Akira
金额：
$ 2.5万
依托单位：
Kyoto University
依托单位国家：
日本
项目类别：
Grant-in-Aid for Challenging Exploratory Research
财政年份：
2012
资助国家：
日本
起止时间：
2012-04-01 至 2014-03-31
项目状态：
已结题

来源：
https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-24659147/
关键词：
免疫学クラススイッチ遺伝子組換えアレルギー免疫制御

项目摘要

Focused on the regulation of IgE production and regulation of class switching to IgA, a trial to manipulate of the target gene specificity of class switch recombination (CSR) by intervening its place or regulatory factors was performed.It was examined whether the specific CSR could be controlled in an in vitro culture by the factors like Id2 and Runx2/3 which are known to be involved in the regulation of CSR to IgE and IgA, respectively. It was also examined whether such factors could guide the cells to switch to IgA after the cells were induced to IgE CSR.By the above experiments, a possibility was tested that intervening the place or regulatory factors of CSR to manipulate specificity of CSR and could be a target to control allergy by eliminating IgE and to strengthen first-line protection against infectious diseases by enhancing IgA production.

本研究以调节IgE的产生和调节向伊加的类别转换为目的，通过干预类别转换重组（CSR）的位置或调节因子来操纵CSR的靶基因特异性，研究了特异性CSR是否可以在体外培养中通过已知参与调节CSR向IgE和伊加的因子如Id 2和Runx 2/3来控制，分别通过上述实验，测试了干预CSR的位置或调节因子以操纵CSR的特异性的可能性，并且可以成为通过消除IgE来控制变态反应和通过增强伊加产生来加强对感染性疾病的第一线保护的靶点。

项目成果

期刊论文数量（10）

专著数量（0）

科研奖励数量（0）

会议论文数量（0）

专利数量（0）

Functional Evaluation of Activation-dependent Alterations in the Sialoglycan Composition of T Cells

DOI：
10.1074/jbc.m113.523753
发表时间：
2014-01-17
期刊：
JOURNAL OF BIOLOGICAL CHEMISTRY
影响因子：
4.8
作者：
Naito-Matsui, Yuko;Takada, Shuhei;Takematsu, Hiromu
通讯作者：
Takematsu, Hiromu

Novel Collagen/Gelatin Scaffold with Sustained Release of Basic Fibroblast Growth Factor: Clinical Trial for Chronic Skin Ulcers

DOI：
10.1089/ten.tea.2012.0634
发表时间：
2013-09-01
期刊：
TISSUE ENGINEERING PART A
影响因子：
4.1
作者：
Morimoto, Naoki;Yoshimura, Kenichi;Suzuki, Shigehiko
通讯作者：
Suzuki, Shigehiko

In situ differentiation of CD8aa T cells from CD4 Tcells in peripheral lymphoid tissues

外周淋巴组织中 CD8aa T 细胞与 CD4 T 细胞的原位分化

DOI：
发表时间：
2012
期刊：
影响因子：
0
作者：
Nambu Y;Hayashi T;Jang KJ;Aoki K;Mano H;Nakano K;Osato M;Takahashi K;Itoh K;Teramukai S;Komori T;Fujita J;Ito Y;Shimizu A;Sugai M
通讯作者：
Sugai M

Evasion from accelerated blood clearance of nanocarrier named as "Lactosome" induced by excessive administration of Lactosome