Search for methods to control and treat allergy by regulating class switch recombination
寻找通过调节类别转换重组来控制和治疗过敏的方法
基本信息
- 批准号:24659147
- 负责人:
- 金额:$ 2.5万
- 依托单位:
- 依托单位国家:日本
- 项目类别:Grant-in-Aid for Challenging Exploratory Research
- 财政年份:2012
- 资助国家:日本
- 起止时间:2012-04-01 至 2014-03-31
- 项目状态:已结题
- 来源:
- 关键词:
项目摘要
Focused on the regulation of IgE production and regulation of class switching to IgA, a trial to manipulate of the target gene specificity of class switch recombination (CSR) by intervening its place or regulatory factors was performed.It was examined whether the specific CSR could be controlled in an in vitro culture by the factors like Id2 and Runx2/3 which are known to be involved in the regulation of CSR to IgE and IgA, respectively. It was also examined whether such factors could guide the cells to switch to IgA after the cells were induced to IgE CSR.By the above experiments, a possibility was tested that intervening the place or regulatory factors of CSR to manipulate specificity of CSR and could be a target to control allergy by eliminating IgE and to strengthen first-line protection against infectious diseases by enhancing IgA production.
以调节IgE的产生和调节类转换为IgA为中心,尝试通过干预类开关重组(CSR)的位置或调节因子来调控CSR的靶基因特异性,以检验在体外培养条件下,特异性CSR能否分别被参与CSR对IgE和IgA的调节的Id2和Runx2/3等因子调控。通过上述实验,验证了通过干预CSR的位置或调节因子来调控CSR的特异性,并可作为通过清除IgE来控制变态反应和通过增加IgA的产生来加强对传染病的一线保护的目标。
项目成果
期刊论文数量(10)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
In situ differentiation of CD8aa T cells from CD4 Tcells in peripheral lymphoid tissues
外周淋巴组织中 CD8aa T 细胞与 CD4 T 细胞的原位分化
- DOI:
- 发表时间:2012
- 期刊:
- 影响因子:0
- 作者:Nambu Y;Hayashi T;Jang KJ;Aoki K;Mano H;Nakano K;Osato M;Takahashi K;Itoh K;Teramukai S;Komori T;Fujita J;Ito Y;Shimizu A;Sugai M
- 通讯作者:Sugai M
Functional Evaluation of Activation-dependent Alterations in the Sialoglycan Composition of T Cells
- DOI:10.1074/jbc.m113.523753
- 发表时间:2014-01-17
- 期刊:
- 影响因子:4.8
- 作者:Naito-Matsui, Yuko;Takada, Shuhei;Takematsu, Hiromu
- 通讯作者:Takematsu, Hiromu
Novel Collagen/Gelatin Scaffold with Sustained Release of Basic Fibroblast Growth Factor: Clinical Trial for Chronic Skin Ulcers
- DOI:10.1089/ten.tea.2012.0634
- 发表时间:2013-09-01
- 期刊:
- 影响因子:4.1
- 作者:Morimoto, Naoki;Yoshimura, Kenichi;Suzuki, Shigehiko
- 通讯作者:Suzuki, Shigehiko
Evasion from accelerated blood clearance of nanocarrier named as "Lactosome" induced by excessive administration of Lactosome
- DOI:10.1016/j.bbagen.2013.03.024
- 发表时间:2013-08-01
- 期刊:
- 影响因子:3
- 作者:Hara, Eri;Makino, Akira;Kimura, Shunsaku
- 通讯作者:Kimura, Shunsaku
An exploratory clinical study on the safety and efficacy of an autologous fibroblast-seeded artificial skin cultured with animal product-free medium in patients with diabetic foot ulcers
- DOI:10.1111/j.1742-481x.2012.01064.x
- 发表时间:2014-04-01
- 期刊:
- 影响因子:3.1
- 作者:Morimoto, Naoki;Ito, Tatsuya;Suzuki, Shigehiko
- 通讯作者:Suzuki, Shigehiko
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SHIMIZU Akira其他文献
International Posture and Personality Traits of Engineering Students' in an EFL Setting
英语环境下工科学生的国际姿态和人格特征
- DOI:
- 发表时间:
2020 - 期刊:
- 影响因子:0
- 作者:
KASHIMURA Mayu;ISHII Eriko;SHIMIZU Akira;NAGATA Hirokazu - 通讯作者:
NAGATA Hirokazu
SHIMIZU Akira的其他文献
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{{ truncateString('SHIMIZU Akira', 18)}}的其他基金
Elevated type I interferon expression in dermatomyositis: involvement of LINE-1 and viral infection.
皮肌炎中 I 型干扰素表达升高:LINE-1 和病毒感染的参与。
- 批准号:
19K08766 - 财政年份:2019
- 资助金额:
$ 2.5万 - 项目类别:
Grant-in-Aid for Scientific Research (C)
Statistical mechanics based on pure quantum states
基于纯量子态的统计力学
- 批准号:
26287085 - 财政年份:2014
- 资助金额:
$ 2.5万 - 项目类别:
Grant-in-Aid for Scientific Research (B)
A Study on Developing English, Chinese and Malay Teaching Materials Based on Communicating in Laboratories of Electronics
基于通信的电子实验室英、华、马来教材开发研究
- 批准号:
26370690 - 财政年份:2014
- 资助金额:
$ 2.5万 - 项目类别:
Grant-in-Aid for Scientific Research (C)
Immunological network in ANCA associated glomerulonephritis
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- 批准号:
24591217 - 财政年份:2012
- 资助金额:
$ 2.5万 - 项目类别:
Grant-in-Aid for Scientific Research (C)
Mutual application of quantum physics and nonequilibrium statistical mechanics
量子物理与非平衡统计力学的相互应用
- 批准号:
22540407 - 财政年份:2010
- 资助金额:
$ 2.5万 - 项目类别:
Grant-in-Aid for Scientific Research (C)
Elucidation of molecular mechanisms for the regulation of immune response by reconstruction of microenvironment and analyses of transcription factors and their networks
通过微环境重建和转录因子及其网络分析阐明免疫反应调节的分子机制
- 批准号:
21390077 - 财政年份:2009
- 资助金额:
$ 2.5万 - 项目类别:
Grant-in-Aid for Scientific Research (B)
Origin of the primitively social behavior in Pompilidae : characteristics of the male matin g behavior and their evolutionary significance
庞皮蜥科原始社会行为的起源:雄性交配行为的特征及其进化意义
- 批准号:
21570100 - 财政年份:2009
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$ 2.5万 - 项目类别:
Grant-in-Aid for Scientific Research (C)
Xenotransplantation from GalT-KO miniture swine to baboon in tolerance induction protocol
在耐受诱导方案中从 GalT-KO 小型猪到狒狒的异种移植
- 批准号:
20591900 - 财政年份:2008
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$ 2.5万 - 项目类别:
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Management Strategy of foreign company in Asia and Oceania
亚洲及大洋洲外资企业经营策略
- 批准号:
18530334 - 财政年份:2006
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$ 2.5万 - 项目类别:
Grant-in-Aid for Scientific Research (C)
A Study on Developing English Teaching Materials Based on Conversations in Laboratories of Electronics
基于电子实验室会话的英语教材开发研究
- 批准号:
18520477 - 财政年份:2006
- 资助金额:
$ 2.5万 - 项目类别:
Grant-in-Aid for Scientific Research (C)
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