Search for methods to control and treat allergy by regulating class switch recombination

寻找通过调节类别转换重组来控制和治疗过敏的方法

• 批准号: 24659147
• 负责人: SHIMIZU Akira
• 金额: $ 2.5万
• 依托单位: Kyoto University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Challenging Exploratory Research
• 财政年份: 2012
• 资助国家: 日本
• 起止时间: 2012-04-01 至 2014-03-31
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-24659147/
• 关键词: 免疫学; クラススイッチ; 遺伝子組換え; アレルギー; 免疫制御

Focused on the regulation of IgE production and regulation of class switching to IgA, a trial to manipulate of the target gene specificity of class switch recombination (CSR) by intervening its place or regulatory factors was performed.It was examined whether the specific CSR could be controlled in an in vitro culture by the factors like Id2 and Runx2/3 which are known to be involved in the regulation of CSR to IgE and IgA, respectively. It was also examined whether such factors could guide the cells to switch to IgA after the cells were induced to IgE CSR.By the above experiments, a possibility was tested that intervening the place or regulatory factors of CSR to manipulate specificity of CSR and could be a target to control allergy by eliminating IgE and to strengthen first-line protection against infectious diseases by enhancing IgA production.

专注于对IgA转换为IgA的IGE产生和调节，通过介入进行诸如ID2和Run condutunty conduction conduction conde conde conde condy conde conde conculation conculation conculation conculation conculation conculation conculation conculation concuntion cons consectig and concuntion cons cons cons consectig and concy的csr是否可以控制特定的CSR，以操纵类转换重组（CSR）的目标基因特异性。 还检查了此类因素是否可以指导细胞在诱导细胞诱导IgE CSR之后切换到IgA。通过上述实验，测试了一种可能性，即介入CSR的位置或调节因素，以操纵CSR的特异性，并可以通过消除IGE来控制IGE并通过增强Infcectious sepease的靶标的目标，以控制一个靶标，以控制过敏。

项目成果

An exploratory clinical study on the safety and efficacy of an autologous fibroblast-seeded artificial skin cultured with animal product-free medium in patients with diabetic foot ulcers

• DOI: 10.1111/j.1742-481x.2012.01064.x
• 发表时间: 2014-04-01
• 期刊: INTERNATIONAL WOUND JOURNAL
• 影响因子: 3.1
• 作者: Morimoto, Naoki;Ito, Tatsuya;Suzuki, Shigehiko
• 通讯作者: Suzuki, Shigehiko

Evasion from accelerated blood clearance of nanocarrier named as "Lactosome" induced by excessive administration of Lactosome

• DOI: 10.1016/j.bbagen.2013.03.024
• 发表时间: 2013-08-01
• 期刊: BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS
• 影响因子: 3
• 作者: Hara, Eri;Makino, Akira;Kimura, Shunsaku
• 通讯作者: Kimura, Shunsaku

Functional Evaluation of Activation-dependent Alterations in the Sialoglycan Composition of T Cells

• DOI: 10.1074/jbc.m113.523753
• 发表时间: 2014-01-17
• 期刊: JOURNAL OF BIOLOGICAL CHEMISTRY
• 影响因子: 4.8
• 作者: Naito-Matsui, Yuko;Takada, Shuhei;Takematsu, Hiromu
• 通讯作者: Takematsu, Hiromu