Search for methods to control and treat allergy by regulating class switch recombination

本研究以调节IgE的产生和调节向伊加的类别转换为目的，通过干预类别转换重组（CSR）的位置或调节因子来操纵CSR的靶基因特异性，研究了特异性CSR是否可以在体外培养中通过已知参与调节CSR向IgE和伊加的因子如Id 2和Runx 2/3来控制，分别 通过上述实验，测试了干预CSR的位置或调节因子以操纵CSR的特异性的可能性，并且可以成为通过消除IgE来控制变态反应和通过增强伊加产生来加强对感染性疾病的第一线保护的靶点。

Focused on the regulation of IgE production and regulation of class switching to IgA, a trial to manipulate of the target gene specificity of class switch recombination (CSR) by intervening its place or regulatory factors was performed.It was examined whether the specific CSR could be controlled in an in vitro culture by the factors like Id2 and Runx2/3 which are known to be involved in the regulation of CSR to IgE and IgA, respectively. It was also examined whether such factors could guide the cells to switch to IgA after the cells were induced to IgE CSR.By the above experiments, a possibility was tested that intervening the place or regulatory factors of CSR to manipulate specificity of CSR and could be a target to control allergy by eliminating IgE and to strengthen first-line protection against infectious diseases by enhancing IgA production.