Screening of sporozoite receptor molecule(s) on hepatocytes
Screening of sporozoite receptor molecule(s) on hepatocytes
批准号:
21390124
负责人:
TORII Motomi
金额:
$11.81万
依托单位:
依托单位国家:
日本
项目类别:
Grant-in-Aid for Scientific Research (B)
财政年份:
2009
资助国家:
日本
项目状态:
已结题
起止时间:
2009 至 2011
中文摘要
用单抗对参与肝细胞感染的子孢子分泌蛋白P36p进行了鉴定。结果表明,P36p在子孢子释放到血淋巴并储存在顶端细胞器微线体后开始表达,直到它们在肝细胞入侵之前或期间被分泌。此外,还鉴定了6个在靶细胞感染期(裂殖子和子孢子)普遍表达的杆状病毒分子。
英文摘要
Characterization of P36p, the sporozoite secreted proteins involved in hepatocyte infection, was performed using monoclonal antibody. It was revealed that P36p starts expression after sporozoites released into hemolymph and stored in microneme, the apical organelle, until they are secreted before or during hepatocyte invasion. Moreover, 6 rhoptry molecules commonly expressed in target cell infective stages(merozoite and sporozoites) were identified.
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熱帯熱マラリア原虫RALP1はロプトリー頸部に局在し密着接合形成に関与する
恶性疟原虫 RALP1 位于棒状体颈部,参与紧密连接形成
DOI:
--
发表时间:
2012
期刊:
影响因子:
--
作者:
[伊藤大輔, 長谷川倫之, 三浦憲豊, Thongkukiatkul Amporn, 竹尾暁, 鳥居本美, 坪井敬文]
通讯作者:
坪井敬文
DOI:
--
发表时间:
2012
期刊:
影响因子:
--
作者:
[石野智子, 村田英理, 徳永順士, 橘真由美, 坪井敬文, 鳥居本美]
通讯作者:
鳥居本美
マラリア原虫スポロゾイトにおけるロプトリータンパク群の性状解析
疟原虫子孢子中棒状体蛋白的表征
DOI:
--
发表时间:
2011
期刊:
影响因子:
--
作者:
[徳永順士, 村田英理, 石野智子, 鳥居本美]
通讯作者:
鳥居本美
マラリア原虫スポロゾイトの肝細胞への侵入過程の real time imaging 解析
疟原虫子孢子侵入肝细胞过程的实时成像分析
DOI:
--
发表时间:
2011
期刊:
影响因子:
--
作者:
[石野智子, Hegge Stephan, 徳永順士, 村田英理, 杉野友香, 鳥居本美]
通讯作者:
鳥居本美
熱帯熱マラリア原虫rhoptry neck protein 3はAMA1非存在下でRON2およびRON4と複合体を形成する
在 AMA1 缺失的情况下,恶性疟原虫棒状体颈蛋白 3 与 RON2 和 RON4 形成复合物
DOI:
--
发表时间:
2011
期刊:
影响因子:
--
作者:
[伊藤大輔, 韓銀澤, 竹尾暁, Thongkukiatkul Amporn, 大槻均, 鳥居本美, 坪井敬文]
通讯作者:
坪井敬文
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依托单位:
海外基金