Cellular signaling system in Psoriatic epidermis

银屑病表皮细胞信号系统

• 批准号: 21390323
• 负责人: IIZUKA Hajime
• 金额: $ 10.4万
• 依托单位: Asahikawa Medical College
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (B)
• 财政年份: 2009
• 资助国家: 日本
• 起止时间: 2009 至 2012
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-21390323/
• 关键词: 乾癬; 表皮細胞; 細胞内情報伝達; ポドプラニン; IL-22; 乾癬表皮細胞; MAP kinase; STAT3; Raf; podoplanin; corneodesmosin; corneodesosin

Podoplanin expression of keratinocytes was induced by IL-22 in a STAT-3-dependent manner. The podoplanin expression was highly upregulated in basal cells of granular layer-negative psoriatic epidermis compared with that of granular layer positive less hyperproliferative epidermis. Furthermore, podoplanin expression was more marked on basal cells of psoriatic rete ridges where stem cell-derived transit amplifying cells are assumed to be located. The finite proliferative potential of transit amplifying cells was confirmed in keratinocyte following podoplanin induction. These results indicate that podoplanin might be a novel marker of transit amplifying cells of epidermis.

角质形成细胞的Podoplanin表达由IL-22以STAT-3依赖的方式诱导。与颗粒层阳性的过度增生表皮相比，颗粒层阴性的银屑病表皮的基底细胞中podoplanin表达显著上调。此外，podoplanin表达更显着的干细胞来源的过境放大细胞位于银屑病网脊的基底细胞。在Podoplanin诱导后的角质形成细胞中证实了转运扩增细胞的有限增殖潜力。这些结果表明，podoplanin可能是一个新的标记物的过渡放大细胞的表皮。

项目成果

Management of patients with psoriasis in Japan

日本银屑病患者的管理

• 发表时间: 2011
• 期刊: Adv Psorisasis & Inflammatory skin diseases
• 作者: Tsuchida M;et al.;Iizuka H
• 通讯作者: Iizuka H

Tight junctions in the stratum crneum explain special differences in corneodesmosome degradation

角质层的紧密连接解释了角质桥粒降解的特殊差异

• 发表时间: 2010
• 作者: Ishida-Yamamoto A;Igawa S;Kishibe M;Murakami M;Honma M;Iizuka H
• 通讯作者: Iizuka H

Lamellar granule secretion starts before the estqablishment of tight junction barrier for paracellular tracers in mammalian epidermis

哺乳动物表皮中细胞旁示踪剂的紧密连接屏障建立之前就开始分泌层状颗粒

• 发表时间: 2012
• 期刊: PloS One
• 影响因子: 3.7
• 作者: Ishida-Yamamoto A;Kishibe M;Murakami M;Honma M;Takahashi H;Iizuka H
• 通讯作者: Iizuka H

Tight junctions in the stratum corneum explain spacial differences in corneodesmosome degradation

角质层的紧密连接解释了角质桥粒降解的空间差异

• 发表时间: 2010
• 期刊: Exp Dermatol
• 影响因子: 3.6
• 作者: Igawa S;Kishibe M;Murakami M Honma M;Takahashi H;Iizuka H;Ishida-Yamamoto A
• 通讯作者: Ishida-Yamamoto A

Podoplanin expression inwound and hyperproliferative psoriatic epidermis : Eegulation by TGF-β and STAT-3 activating cytokines

伤口和过度增殖性银屑病表皮中足平蛋白的表达：TGF-β和STAT-3激活细胞因子的调节

• 发表时间: 2012
• 期刊: Journal of Dermatological Science
• 影响因子: 4.6
• 作者: Honma;Minami-Hori;Takahashi;Iizuka
• 通讯作者: Iizuka