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Cellular signaling system in Psoriatic epidermis

Cellular signaling system in Psoriatic epidermis
银屑病表皮细胞信号系统
批准号:
21390323
负责人:
IIZUKA Hajime
金额:
$10.4万
依托单位:
依托单位国家:
日本
项目类别:
Grant-in-Aid for Scientific Research (B)
财政年份:
2009
资助国家:
日本
项目状态:
已结题
起止时间:
2009 至 2012

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中文摘要
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英文摘要
Podoplanin expression of keratinocytes was induced by IL-22 in a STAT-3-dependent manner. The podoplanin expression was highly upregulated in basal cells of granular layer-negative psoriatic epidermis compared with that of granular layer positive less hyperproliferative epidermis. Furthermore, podoplanin expression was more marked on basal cells of psoriatic rete ridges where stem cell-derived transit amplifying cells are assumed to be located. The finite proliferative potential of transit amplifying cells was confirmed in keratinocyte following podoplanin induction. These results indicate that podoplanin might be a novel marker of transit amplifying cells of epidermis.
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Management of patients with psoriasis in Japan
日本银屑病患者的管理
DOI: --
发表时间: 2011
期刊: Adv Psorisasis & Inflammatory skin diseases
影响因子: --
作者: [Tsuchida M, et al., Iizuka H]
通讯作者: Iizuka H
Tight junctions in the stratum crneum explain special differences in corneodesmosome degradation
角质层的紧密连接解释了角质桥粒降解的特殊差异
DOI: --
发表时间: 2010
期刊:
影响因子: --
作者: [Ishida-Yamamoto A, Igawa S, Kishibe M, Murakami M, Honma M, Iizuka H]
通讯作者: Iizuka H
Lamellar granule secretion starts before the estqablishment of tight junction barrier for paracellular tracers in mammalian epidermis
哺乳动物表皮中细胞旁示踪剂的紧密连接屏障建立之前就开始分泌层状颗粒
DOI: --
发表时间: 2012
期刊: PloS One
影响因子: 3.7
作者: [Ishida-Yamamoto A, Kishibe M, Murakami M, Honma M, Takahashi H, Iizuka H]
通讯作者: Iizuka H
Tight junctions in the stratum corneum explain spacial differences in corneodesmosome degradation
角质层的紧密连接解释了角质桥粒降解的空间差异
DOI: --
发表时间: 2010
期刊: Exp Dermatol
影响因子: 3.6
作者: [Igawa S, Kishibe M, Murakami M Honma M, Takahashi H, Iizuka H, Ishida-Yamamoto A]
通讯作者: Ishida-Yamamoto A
26
    Analysis of Mutated SERCA2b transgenic mouse
    • 批准号:
      17390309
    • 项目类别:
      Grant-in-Aid for Scientific Research (B)
    • 资助金额:
      $6.98万
    • 财政年份:
      2005
    • 负责人:
      IIZUKA Hajime
    • 依托单位:
    Kinetic propertie of three Darier disease SERCA26 mutants.
    • 批准号:
      14370256
    • 项目类别:
      Grant-in-Aid for Scientific Research (B)
    • 资助金额:
      $5.44万
    • 财政年份:
      2002
    • 负责人:
      IIZUKA Hajime
    • 依托单位:
    DISORGANIZED REGULATION OF CELL PROLIFERATION AND KERATINIZATION OF PSORIATIC EPIDERMIS : ANALYSIS OF DERANGED SIGNALING SYSTEM.
    • 批准号:
      08457233
    • 项目类别:
      Grant-in-Aid for Scientific Research (B)
    • 资助金额:
      $4.54万
    • 财政年份:
      1996
    • 负责人:
      IIZUKA Hajime
    • 依托单位:
    Computer Operation Support System to Establish Elementary Education of Computer Science
    • 批准号:
      06558026
    • 项目类别:
      Grant-in-Aid for Developmental Scientific Research (B)
    • 资助金额:
      $0.96万
    • 财政年份:
      1994
    • 负责人:
      IIZUKA Hajime
    • 依托单位:
    海外基金