Identification and quantitation of low abundant tumor marker candidates in plasma derived from cancer tissue using recent proteomic technologies
Identification and quantitation of low abundant tumor marker candidates in plasma derived from cancer tissue using recent proteomic technologies
批准号:
21390354
负责人:
TOMONAGA Takeshi
金额:
$11.65万
依托单位国家:
日本
项目类别:
Grant-in-Aid for Scientific Research (B)
财政年份:
2009
资助国家:
日本
项目状态:
已结题
起止时间:
2009 至 2011
中文摘要
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英文摘要
Recent advance of proteomic technology have contributed to identify biomarkers for various disease, however, only a few proteins have been used in practical application. This study was aimed to identify and quantitate low abundant tumor marker candidates in plasma derived from cancer tissue using recent proteomic technologies. About 5000 membrane proteins from colorectal and breast cancer tissues were identified respectively. Among them, about 100 colorectal and 20 breast cancer biomarker candidate proteins were verified by SRM/MRM method. Some of the candidate proteins were detected in human serum.
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近年のプロテオミクス技術の進歩とそのがん研究への応用
蛋白质组学技术的最新进展及其在癌症研究中的应用
DOI:
--
发表时间:
2010
期刊:
影响因子:
--
作者:
[Kamiyam T, Nakanishi K, Yokoo H, Kamachi H, Tahara M, Suzuki T, Shimamura T, Furukawa H, Matsushita M, Todo S, 朝長毅]
通讯作者:
朝長毅
最近のプロテオミクスの進歩~ターゲットプロテオミクス:翻訳後修飾解析とSRMを用いた絶対定量~
蛋白质组学的最新进展 - 靶向蛋白质组学:使用翻译后修饰分析和 SRM 进行绝对定量 -
DOI:
--
发表时间:
2010
期刊:
影响因子:
--
作者:
[Shuji Miyagawa, Shunsaku Takeishi, Aki Yamamoto, Kosuke Ikeda, Hitomi Matsunari, Hiroshi Nagashima, Masao Yamada, Eiji Miyoshi, Masahiro Fukuzawa, 朝長毅]
通讯作者:
朝長毅
大腸がんにおけるバイオマーカー研究のためのプロテオミクス
结直肠癌生物标志物研究的蛋白质组学
DOI:
--
发表时间:
2011
期刊:
影响因子:
--
作者:
[Ichinohe N, Kon J, Mitaka T, 杉原豊]
通讯作者:
杉原豊
定量的リン酸化プロテオミクスによる乳癌の予後不良群と予後良好群の比較
使用定量磷酸蛋白质组学比较预后不良和预后良好的乳腺癌
DOI:
--
发表时间:
2010
期刊:
影响因子:
--
作者:
[Masuda Y, Nakazawa Y, Matsuda K, Sano K, Mita A, Ohno Y, Urata K, Ikegami T, Miwa S, Miyagawa S, 鳴海良平]
通讯作者:
鳴海良平
The human urinary proteome analysis and high-accuracy proteome database, MAPU.
人类尿液蛋白质组分析和高精度蛋白质组数据库,MAPU。
DOI:
--
发表时间:
2010
期刊:
影响因子:
--
作者:
[Qi F, Li A, Inagaki Y, Kokudo N, et al., Jun Adachi]
通讯作者:
Jun Adachi
共 87 条
Discovery of predictive biomarkers for molecular target drug effectiveness of advanced colorectal cancer using phosphoproteomics
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批准号:24659622
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项目类别:Grant-in-Aid for Challenging Exploratory Research
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资助金额:$2.41万
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财政年份:2012
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负责人:TOMONAGA Takeshi
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依托单位:
Proteome analysis for early diagnosis and treatment of human solid tumors using various proteomic approaches
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批准号:16390353
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项目类别:Grant-in-Aid for Scientific Research (B)
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资助金额:$9.22万
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财政年份:2004
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负责人:TOMONAGA Takeshi
-
依托单位:
海外基金