Mechanism for determination of synaptic critical period in brains

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Mechanism for determination of synaptic critical period in brains Chondroitin sulfate proteoglycans(CSPGs) are main components of extracellular matrix in the mammalian brains and possibly concerned with synaptic plasticity. The present study reveals that tPA-plasminogen system is responsible for synaptic plasticity in the hypothalamic vasopressinergic neurons in vivo. Moreover, it is shown that CSPG-degrading enzyme Chase increases the expression of a synaptic plasticity marker GAP-43 in cultured hippocampal neurons in vitro. Thus, the present results demonstrates that CSPGs are crucial role in synaptic plasticity by regulating their expression.