The creation and application of lifestyle-related diseases in the hyperlipidemia mouse.

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We evaluated the effect of high cholesterol diet on endothelial function of artery from European wood mice(Apodemus Sylvaticus), some of which spontaneously exhibit hyperlipidemia on a normal diet. According to the plasma cholesterol level, mice were divided into two groups ; hypercholesterol mice and normocholesterol mice. Both mice were fed with a normal or high-cholesterol diet for 5 weeks. The high-cholesterol diet increased the total plasma cholesterol level in both groups. The endothelium-dependent relaxation of isolated aorta was worsened in both mice after high cholesterol feeding. Thus, the endothelium-dependent relaxation was inhibited depending on the total plasma cholesterol level.