Development of near-IR responsive triple-targeting anti-cancer drug using efficient silyl-photosensitizer

利用高效甲硅烷基光敏剂开发近红外响应三靶向抗癌药物

• 批准号: 23750145
• 负责人: HORIUCHI Hiroaki
• 金额: $ 3万
• 依托单位: Gunma University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Young Scientists (B)
• 财政年份: 2011
• 资助国家: 日本
• 起止时间: 2011 至 2012
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-23750145/
• 关键词: がん; 光; 治療; 一重項酸素; 近赤外光; 光機能物質; 光線力学療法; 光増感剤; ドラッグデリバリー

To develop the near-IR responsive anticancer drug, we have developed the near-IR responsive drug delivery system, which consists with nanosized drug carrier, olefin unit, and photosensitizer, and efficient near-IR responsive photosensitizer.We have estimated the dissociation efficiency of olefin unit by singlet oxygen and have discussed the possibility to release the photosensitizer from the nanosized carrier. We have also improve the photosensitizer by tuning light absorption efficiency.

为了开发近红外响应的抗癌药物，我们研制了由纳米药物载体、烯烃单元和光敏剂组成的近红外响应的药物传递系统和高效的近红外响应的光敏剂，并估算了单重态氧对烯烃单元的解离效率，探讨了光敏剂从纳米载体中释放的可能性。我们还通过调节光吸收效率来改进光敏剂。

项目成果

Singlet molecular oxygen generation by water-soluble phthalocyanine dendrimers with different aggregation behavior

• DOI: 10.1142/s1088424611003008
• 发表时间: 2011
• 期刊: Journal of Porphyrins and Phthalocyanines
• 影响因子: 1.5
• 作者: M. Nishida;Hiroaki Horiuchi;A. Momotake;Y. Nishimura;H. Hiratsuka;T. Arai

Improvements of Light Absorption Efficiency of Silyl-photosensitizing Drug forPhotodynamic Therapy

光动力治疗用甲硅烷基光敏药物光吸收效率的提高

• 发表时间: 2012
• 作者: H. Horiuchi;R. Ikeda;S. Akiyama,S. Ito;Y. Gomibuchi;Y. Saito;M. Hosaka;T. Okutsu
• 通讯作者: T. Okutsu

Protein Crystallization Induced by Strong Photons-molecules Coupling Fields Photochemical Reaction

强光子-分子耦合场光化学反应诱导蛋白质结晶

• DOI: 10.1016/j.jphotochem.2011.03.012
• 发表时间: 2011
• 期刊: J. Photochem. Photobiol. A: Chem.
• 作者: 関口翔太;新倉謙一;松尾保孝;居城邦治;遠藤洋史;Susumu Haruta
• 通讯作者: Susumu Haruta

含ケイ素置換基を導入した一重項酸素 発生剤

推出含硅取代基的单线态氧发生器

• 发表时间: 2012

シリル基を導入したポルフィリン類の近赤外領域における吸収特性の改善

引入甲硅烷基的卟啉近红外区吸收性能的改善

• 发表时间: 2013
• 作者: W. Liang;C. Yang;D. Zhou;H. Haneoka;M. Nishijima;G. Fukuhara;T. Mori;F. Castiglione;A. Mele;F. Caldera;F. Trotta;Y. Inoue;秋山真吾・堀内宏明・伊藤智志・奥津哲夫・飛田成史・吉原利忠
• 通讯作者: 秋山真吾・堀内宏明・伊藤智志・奥津哲夫・飛田成史・吉原利忠