Pathologic analyses of developmental mechanisms and biological characteristics of breast neuroendocrine tumors (B-NET)

我们将乳腺神经内分泌导管原位癌(NE-DCIS)描述为具有特征性的临床病理特征，如出血的乳头溢液、术前诊断的低频率和低级别的病理参数，从而与非NE-DCIS区分开来，从而将该癌描述为DCIS的一个独特的变种(组织病理学，2008)。细胞病理学，2011年。帕索尔国际公司，2011年。J Clin Pathol，2011。USCAP，2010和2011)。NE-DCIS是一个肿瘤实体，对于了解乳腺神经内分泌肿瘤(B-Net)的组织起源和自然病程具有重要意义，因为NE-DCIS可以被视为B-Net的侵袭前对应物。

We have described breast neuroendocrine ductal carcinoma in situ (NE-DCIS) as having characteristic clinicopathological features, such as bloody nipple discharge, low frequency of preoperative diagnosis and low-grade pathological parameters, allowing differentiation from non-NE-DCIS and, consequently, delineating this carcinoma as a distinctive variant of DCIS (Histopathology, 2008. Cytopathology, 2011. Pathol Int, 2011. J Clin Pathol, 2011. USCAP, 2010 & 2011). NE-DCIS is a tumor entity which is important for understanding the histogenesis and natural history of breast neuroendocrine tumors (B-NET), because NE-DCIS can be regarded as a preinvasive counterpart of B-NET.