Elucidation of mechanism for polarized regulation of viral RNA synthesis of negative-strand RNA viruses

为了阐明病毒高效复制所需的病毒RNA合成极化调控机制，我们发现仙台病毒（仙台病毒是负链病毒的原型）的辅助蛋白之一C蛋白，以时间依赖性的方式下调（+）感病毒RNA合成，并最大限度地产生感染性子代病毒粒子。此外，在本研究过程中，我们还发现了C蛋白调节病毒RNA合成以逃避宿主先天免疫检测的可能性。

In this study aimed at elucidation of mechanism of polarized regulation of viral RNA synthesis, which should be required for efficient viral replication, we found that the C protein, one of the accessory protein of Sendai virus, a prototype of negative-stranded viruses, down-regulated (+)-sense viral RNA synthesis in a time-dependent manner and maximized production of infectious progeny virions. In addition, in the course of this study, we also found a possibility that the C protein regulate viral RNA synthesis to escape from detection by host innate immunity.