Elucidation of mechanism for polarized regulation of viral RNA synthesis of negative-strand RNA viruses

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In this study aimed at elucidation of mechanism of polarized regulation of viral RNA synthesis, which should be required for efficient viral replication, we found that the C protein, one of the accessory protein of Sendai virus, a prototype of negative-stranded viruses, down-regulated (+)-sense viral RNA synthesis in a time-dependent manner and maximized production of infectious progeny virions. In addition, in the course of this study, we also found a possibility that the C protein regulate viral RNA synthesis to escape from detection by host innate immunity.