Basic study of plasma CTGF as a useful biomarker for hypertensive cardiac hypertrophy

我研究了实验性压力超负荷（PO）大鼠血清（或血浆）CTGF水平与心肌肥厚进展的关系。术后2周内部分大鼠心肌CTGF水平升高，但与假手术组比较差异无统计学意义（P> 0.05）。术后第3周，PO组大鼠左室壁厚度明显增加，但CTGF水平在两组之间相似。

I studied the association of serum (or plasma) CTGF levels with progression of cardiac hypertrophy in experimentally pressure-overloaded (PO) rats. The CTGF levels were increased in some rats within 2 weeks after operation without left ventricular hypertrophy, but no statistical significant difference was found between the PO and the sham groups. There were significant increases in left ventricular wall thickness of the PO rats after the third week of the operation, but the CTGF levels were similar between the two groups.