Basic study of plasma CTGF as a useful biomarker for hypertensive cardiac hypertrophy

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I studied the association of serum (or plasma) CTGF levels with progression of cardiac hypertrophy in experimentally pressure-overloaded (PO) rats. The CTGF levels were increased in some rats within 2 weeks after operation without left ventricular hypertrophy, but no statistical significant difference was found between the PO and the sham groups. There were significant increases in left ventricular wall thickness of the PO rats after the third week of the operation, but the CTGF levels were similar between the two groups.