Development of immunotherapy using features of innate immunity and liver dendritic cells
Development of immunotherapy using features of innate immunity and liver dendritic cells
批准号:
21790669
负责人:
ABE Masanori
金额:
$2.66万
依托单位:
依托单位国家:
日本
项目类别:
Grant-in-Aid for Young Scientists (B)
财政年份:
2009
资助国家:
日本
项目状态:
已结题
起止时间:
2009 至 2010
中文摘要
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英文摘要
In this study, we conducted basic research for the development of immunotherapy using liver dendritic cells (DC) and innate immunity. We found that, due to the hyporesponsiveness to endotxin, liver DC stimulated by innate immune signal had less immunogenicity compared to DC from other organs both in vitro and in vivo. These data indicate that it is necessary to consider the balance between maintenance and break endotoxin tolerance for the development of immunotherapy in liver diseases.
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发表时间:
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期刊:
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[阿部雅則, 吉田理, 濱田麻穂, 道堯浩二郎, 堀池典生, 日浅陽一, 恩地森一]
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TLR配体对肝树突状细胞迁移能力的影响
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发表时间:
2009
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作者:
[阿部雅則, 吉田理, 濱田麻穂, 三宅映己, 多田藤政, 日浅陽一, 恩地森一]
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发表时间:
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2009
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共 15 条
Contribution of USF1 on development of diabetic kidney disease and the drug discovery of PI polyamides to block the USF1 binding
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批准号:20K08599
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项目类别:Grant-in-Aid for Scientific Research (C)
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资助金额:$2.75万
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财政年份:2020
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负责人:ABE Masanori
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依托单位:
Suppressive effects of pyrrole-imidazole polyamides targeting TGF-beta1 as novel biomedicines on the diabetic nephropathy
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批准号:17K09716
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项目类别:Grant-in-Aid for Scientific Research (C)
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资助金额:$2.91万
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财政年份:2017
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负责人:ABE Masanori
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依托单位:
Development and diagnosis/therapy application of magnetic beads exhibiting surface/uptake affinity to cancer cells
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批准号:18209019
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项目类别:Grant-in-Aid for Scientific Research (A)
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资助金额:$31.03万
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财政年份:2006
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负责人:ABE Masanori
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依托单位:
Applying ferrite nanobeads to medical diagnosis, therapy and analysis
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批准号:15209019
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项目类别:Grant-in-Aid for Scientific Research (A)
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资助金额:$32.45万
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财政年份:2003
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负责人:ABE Masanori
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依托单位:
Research Study on "Satoyama" Program To Experience A Natural Environment And Traditional Technology
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批准号:13680223
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项目类别:Grant-in-Aid for Scientific Research (C)
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资助金额:$2.56万
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财政年份:2001
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负责人:ABE Masanori
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依托单位:
Magnetic probe with ferrite couples to bioligands for diagnostic and clinical uses
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批准号:12309004
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项目类别:Grant-in-Aid for Scientific Research (A)
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资助金额:$20.54万
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财政年份:2000
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负责人:ABE Masanori
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依托单位:
Preparation of magnetic films by new technique "ultrasound enhanced" ferrite plating
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批准号:08455137
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项目类别:Grant-in-Aid for Scientific Research (B)
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资助金额:$4.99万
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财政年份:1996
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负责人:ABE Masanori
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依托单位:
Fabrication of Micro/Millimeter Wave Integrated Circuit by Novel Ferrite Plating Enhanced by Laser
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批准号:05555086
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项目类别:Grant-in-Aid for Developmental Scientific Research (B)
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资助金额:$14.34万
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财政年份:1993
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负责人:ABE Masanori
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依托单位:
Small radius artificial blood vessel with a high endothelial reorganization effect by static magnetic stray field from ferrite coating
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批准号:05454693
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项目类别:Grant-in-Aid for General Scientific Research (B)
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资助金额:$4.22万
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财政年份:1993
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负责人:ABE Masanori
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依托单位:
Development of Fine Crystal-Dispersed Transparent Materials for Optical Devices
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批准号:02650214
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项目类别:Grant-in-Aid for General Scientific Research (C)
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资助金额:$1.86万
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财政年份:1990
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负责人:ABE Masanori
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依托单位:
Preparation of New Magnetic Devices by "Light-Enhanced" Ferrite Plating
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批准号:02555058
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项目类别:Grant-in-Aid for Developmental Scientific Research (B)
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资助金额:$8.77万
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财政年份:1990
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负责人:ABE Masanori
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依托单位:
Study on Bi-Substituted Garnet Films with Strong Magneto-Optical Activity and High Corrosion Resistance for Magneto-Optical Disc.
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批准号:61550223
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项目类别:Grant-in-Aid for General Scientific Research (C)
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资助金额:$1.41万
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财政年份:1986
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负责人:ABE Masanori
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依托单位:
Developing Magneto-optical discs by applying new technology derrite platir
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批准号:60850059
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项目类别:Grant-in-Aid for Developmental Scientific Research
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资助金额:$4.8万
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财政年份:1985
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负责人:ABE Masanori
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依托单位:
海外基金