A role of muscle-restricted coiled-coil protein (MURC) in cardiac hypertrophy and heart failure

肌肉限制性卷曲螺旋蛋白（MURC）在心脏肥大和心力衰竭中的作用

• 批准号: 21790703
• 负责人: OGATA TAKEHIRO
• 金额: $ 2.75万
• 依托单位: Kyoto Prefectural University of Medicine
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Young Scientists (B)
• 财政年份: 2009
• 资助国家: 日本
• 起止时间: 2009 至 2010
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-21790703/
• 关键词: 筋特異的遺伝子; 心肥大; 心不全

MURC expression was increased in cardiac hypertrophy and failing hearts. When MURC was overexpressed in CMs, MURC induced ERK activation and cardiomyocyte (CM) hypertrophy. shRNA-mediated MURC knockdown impaired α1 adrenergic agonist-induced CM hypertrophy and ERK activation. MURC-induced increases in cell size were attenuated by a MEK inhibitor. Furthermore, MURC bound to cavin family proteins (cavin-1, -2), caveolin-3, α1 adrenergic receptor, and p-ERK in CMs.

MURC表达在心肌肥厚和衰竭心脏中增加。当MURC在CM中过表达时，MURC诱导ERK激活和心肌细胞（CM）肥大。shRNA介导的MURC敲低损害α1肾上腺素能激动剂诱导的CM肥大和ERK激活。MRC诱导的细胞大小增加被MEK抑制剂减弱。此外，在CM中，MURC与cavin家族蛋白（cavin-1、-2）、caveolin-3、α1肾上腺素能受体和p-ERK结合。

项目成果

MURC, Muscle-restricted coiled-coil protein, regulates caveolae morphology and induces hypertrophy in cardiomyocytes.

MURC，肌肉限制性卷曲螺旋蛋白，调节小凹形态并诱导心肌细胞肥大。

• 发表时间: 2010
• 作者: Taniguchi T;Ogata T;Naito D;Nakanishi N;Miyagawa K;Amano K;Isodono K;Imoto H;Tagawa M;Takehara N;Asada S;Adachi A;Morimoto M;Takahashi T;Oh H;Ueyama T;Matsubara H.
• 通讯作者: Matsubara H.

MURC, a muscle-restricted coiled-coil protein, is involved in the regulation of skeletal myogenesis.

• DOI: 10.1152/ajpcell.00188.2008
• 发表时间: 2008-08
• 期刊: American journal of physiology. Cell physiology
• 作者: M. Tagawa;T. Ueyama;T. Ogata;N. Takehara;Norio Nakajima;K. Isodono;S. Asada;Tomosaburo Takahashi;H. Matsubara;H. Oh

PARM-1 is an endoplasmic reticulum molecule involved in endoplasmic reticulum stress-induced apoptosis in rat cardiac myocytes.

• DOI: 10.1371/journal.pone.0009746
• 发表时间: 2010-03-18
• 期刊: PloS one
• 影响因子: 3.7
• 作者: Isodono K;Takahashi T;Imoto H;Nakanishi N;Ogata T;Asada S;Adachi A;Ueyama T;Oh H;Matsubara H
• 通讯作者: Matsubara H

PARM-1 is an Endoplasmic Reticulum Molecule Involved in Endoplasmic Reticulum Stress-induced Apoptosis in Rat Cazdiac Myocytes.

PARM-1 是一种内质网分子，参与大鼠 Cazdiac 肌细胞内质网应激诱导的细胞凋亡。

• 发表时间: 2010
• 期刊: PLoS ONE
• 影响因子: 3.7
• 作者: 五十殿弘二、小形岳寛;他
• 通讯作者: 他

MURC Induces Cardiomyocyte Hypertrophy Through The Extracellular Signal-regulated Kinase Pathway.

MURC 通过细胞外信号调节激酶途径诱导心肌细胞肥大。

• 发表时间: 2010
• 作者: 内藤大督、小形岳寛;他
• 通讯作者: 他