The effect of maternal immunity on the onset of infant asthma.

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By sensitizing mother before pregnancy and inducing allergic airway inflammation during pregnancy, serum OVA-specific IgE level and sensitivity for asthma was significantly reduced in wild-type offspring. It was assumed that maternal passive immunity by the transportation of antigen specific IgG may regulate allergic airway inflammation. The administration of antigen specific IgG into mother mice during lactating period reduced airway inflammation of offspring in wild type mice, but not in FcRn deficient mice. It is concluded that he transfer of maternal antigen-specific IgG regulates the development of allergic airway inflammation early in life in the FcRn-dependent manner.