Development of inhaled biodegradable nano/micro-particles incorporated immuno-modulatory DNA for treatment of inflammatory lung diseases
Development of inhaled biodegradable nano/micro-particles incorporated immuno-modulatory DNA for treatment of inflammatory lung diseases
批准号:
21790778
负责人:
SATO Takashi
金额:
$2.75万
依托单位:
依托单位国家:
日本
项目类别:
Grant-in-Aid for Young Scientists (B)
财政年份:
2009
资助国家:
日本
项目状态:
已结题
起止时间:
2009 至 2010
中文摘要
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英文摘要
Recently we have developed biomaterials incorporated oligodeoxynucleotide (ODN) achieving acceleration of epithelial cell repair. In this regard, we focused on the effective delivery of ODN to pulmonary immune cells such as alveolar macrophages and bronchial associated lymphoid tissue. Finally, we synthesized biodegradable polyketal nano-particles containing ODN, which showed sustaining-hydrolyzed and preferably degraded in acidic condition. Thereby, we could extend our studies in the local administrative inhaled approach in lung inflammation study.
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DOI:
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发表时间:
期刊:
影响因子:
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作者:
[]
通讯作者:
Therapeutic Application and Mechanisms Underlyinng the Activity of Immunosupp ressive Oligonucleotides
免疫抑制寡核苷酸的治疗应用和活性机制
DOI:
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发表时间:
2009
期刊:
Ann NY Acad Sci 1175
影响因子:
--
作者:
[Klinman DM. Tross D, Klaschik S, Shirota H, Sato T]
通讯作者:
Sato T
CpG oligodeoxynucleotide incorporated basement membrane extract facilitate wound repair in mice.
掺入 CpG 寡脱氧核苷酸的基底膜提取物促进小鼠伤口修复。
DOI:
--
发表时间:
2009
期刊:
影响因子:
--
作者:
[Sato T, Shimosato T, Klinman DM]
通讯作者:
Klinman DM
CpG oligodeoxynucleotide from Streptococcus thermophilus lacZ strongly induces the expression of interleukin-33 in murine immune cells
嗜热链球菌 lacZ 的 CpG 寡脱氧核苷酸强烈诱导小鼠免疫细胞中白细胞介素 33 的表达
DOI:
--
发表时间:
2009
期刊:
影响因子:
--
作者:
[Shimosato T, Tohno M, Sato T, Tateo M, Otani H, Kitazawa H]
通讯作者:
Kitazawa H
DOI:
--
发表时间:
2009
期刊:
Advaced Drug Delivery Reviews 61
影响因子:
--
作者:
[Klinman DM, Klaschik S, Sato T, et al.]
通讯作者:
et al.
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Effect of irrigated paddy rice and upland crop rotation on diversity of soybean rhizobia.
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