Development of inhaled biodegradable nano/micro-particles incorporated immuno-modulatory DNA for treatment of inflammatory lung diseases
Development of inhaled biodegradable nano/micro-particles incorporated immuno-modulatory DNA for treatment of inflammatory lung diseases
批准号:
21790778
负责人:
SATO Takashi
金额:
$2.75万
依托单位:
依托单位国家:
日本
项目类别:
Grant-in-Aid for Young Scientists (B)
财政年份:
2009
资助国家:
日本
项目状态:
已结题
起止时间:
2009 至 2010
中文摘要
近年来,我们开发了含有寡脱氧核苷酸(ODN)的生物材料,以加速上皮细胞的修复。在这方面,我们重点研究了ODN对肺泡巨噬细胞和支气管相关淋巴组织等肺免疫细胞的有效递送。最后,我们合成了含有ODN的可生物降解的聚酮纳米颗粒,该颗粒表现出持续水解和在酸性条件下较好的降解性。因此,我们可以扩大局部行政吸入入路在肺部炎症研究中的研究。
英文摘要
Recently we have developed biomaterials incorporated oligodeoxynucleotide (ODN) achieving acceleration of epithelial cell repair. In this regard, we focused on the effective delivery of ODN to pulmonary immune cells such as alveolar macrophages and bronchial associated lymphoid tissue. Finally, we synthesized biodegradable polyketal nano-particles containing ODN, which showed sustaining-hydrolyzed and preferably degraded in acidic condition. Thereby, we could extend our studies in the local administrative inhaled approach in lung inflammation study.
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DOI:
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发表时间:
期刊:
影响因子:
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作者:
[]
通讯作者:
Therapeutic Application and Mechanisms Underlyinng the Activity of Immunosupp ressive Oligonucleotides
免疫抑制寡核苷酸的治疗应用和活性机制
DOI:
--
发表时间:
2009
期刊:
Ann NY Acad Sci 1175
影响因子:
--
作者:
[Klinman DM. Tross D, Klaschik S, Shirota H, Sato T]
通讯作者:
Sato T
CpG oligodeoxynucleotide incorporated basement membrane extract facilitate wound repair in mice.
掺入 CpG 寡脱氧核苷酸的基底膜提取物促进小鼠伤口修复。
DOI:
--
发表时间:
2009
期刊:
影响因子:
--
作者:
[Sato T, Shimosato T, Klinman DM]
通讯作者:
Klinman DM
CpG oligodeoxynucleotide from Streptococcus thermophilus lacZ strongly induces the expression of interleukin-33 in murine immune cells
嗜热链球菌 lacZ 的 CpG 寡脱氧核苷酸强烈诱导小鼠免疫细胞中白细胞介素 33 的表达
DOI:
--
发表时间:
2009
期刊:
影响因子:
--
作者:
[Shimosato T, Tohno M, Sato T, Tateo M, Otani H, Kitazawa H]
通讯作者:
Kitazawa H
DOI:
--
发表时间:
2009
期刊:
Advaced Drug Delivery Reviews 61
影响因子:
--
作者:
[Klinman DM, Klaschik S, Sato T, et al.]
通讯作者:
et al.
共 14 条
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Study of nanoparticles-incorporating immune modulating oligodeoxynucleotide for the treatment of lung diseases
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Development of drugs targeting secretory inhibition of transthyretin for familial amyloidotic polyneuropathy
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Study of inhaled nanoparticles incorporating synthetic oligodeoxynucleotides to treat lung diseases
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A Study in Dynamics of BEI Expression in 3 Prefectures in Northern Kanto Region
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Investigation for the nuculear receptor functions to cure clonic inflammatory syndrome
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Stabilization and Emergence of Rule Dynamics in Dynamic Cognitive Agents with Internal Dynamics
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Oscillation characteristics improvement of a Vertical Cavity Surface Emitting Laser and consideration to its application
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Molecular mechanisms of gefitinib-induced rash formation: Gefitinib augments lipogenesis and steroidgenesis in sebaceous glands
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Acceleration of Timing Analysis using Monte Carlo Methods
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A History of Modern Jewish Thought and Radical Historicality : Comparative Studies of Franz Rosenzweig and Leo Strauss
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Advance of a new decision theory involving cognition process of agent in economics and game theory
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项目类别:Grant-in-Aid for Young Scientists (Start-up)
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Investigation of mechanisms for the maintenance of cell polarity in epithelial and neuronal cells
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Effect of irrigated paddy rice and upland crop rotation on diversity of soybean rhizobia.
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Integrated research on history of art craft and archaeology that studies on Zeze-Yaki to clarify a process of establishment of Kansai ceramic technology
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A Research on the Problems of Education and the Process and Requirement for the Development of Teacher Professionalism in this modern society
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Policy Designs for Environmental Quality and Fertility
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批准号:16530215
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Studies on the mechanism for generation of factors regulating formation and stabilization of plaques in atherosclerosis.
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Identification of Human facilitating cells
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海外基金