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Development of inhaled biodegradable nano/micro-particles incorporated immuno-modulatory DNA for treatment of inflammatory lung diseases

Development of inhaled biodegradable nano/micro-particles incorporated immuno-modulatory DNA for treatment of inflammatory lung diseases
开发吸入性可生物降解的纳米/微粒,掺入免疫调节 DNA,用于治疗炎症性肺部疾病
批准号:
21790778
负责人:
SATO Takashi
金额:
$2.75万
依托单位:
依托单位国家:
日本
项目类别:
Grant-in-Aid for Young Scientists (B)
财政年份:
2009
资助国家:
日本
项目状态:
已结题
起止时间:
2009 至 2010

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中文摘要
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英文摘要
Recently we have developed biomaterials incorporated oligodeoxynucleotide (ODN) achieving acceleration of epithelial cell repair. In this regard, we focused on the effective delivery of ODN to pulmonary immune cells such as alveolar macrophages and bronchial associated lymphoid tissue. Finally, we synthesized biodegradable polyketal nano-particles containing ODN, which showed sustaining-hydrolyzed and preferably degraded in acidic condition. Thereby, we could extend our studies in the local administrative inhaled approach in lung inflammation study.
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DOI: --
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作者: []
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DOI: --
发表时间: 2009
期刊: Ann NY Acad Sci 1175
影响因子: --
作者: [Klinman DM. Tross D, Klaschik S, Shirota H, Sato T]
通讯作者: Sato T
CpG oligodeoxynucleotide incorporated basement membrane extract facilitate wound repair in mice.
掺入 CpG 寡脱氧核苷酸的基底膜提取物促进小鼠伤口修复。
DOI: --
发表时间: 2009
期刊:
影响因子: --
作者: [Sato T, Shimosato T, Klinman DM]
通讯作者: Klinman DM
CpG oligodeoxynucleotide from Streptococcus thermophilus lacZ strongly induces the expression of interleukin-33 in murine immune cells
嗜热链球菌 lacZ 的 CpG 寡脱氧核苷酸强烈诱导小鼠免疫细胞中白细胞介素 33 的表达
DOI: --
发表时间: 2009
期刊:
影响因子: --
作者: [Shimosato T, Tohno M, Sato T, Tateo M, Otani H, Kitazawa H]
通讯作者: Kitazawa H
14
    Peptide ligand screening of transthyretin protein-protein interaction inhibitor using phage display system
    • 批准号:
      16K18875
    • 项目类别:
      Grant-in-Aid for Young Scientists (B)
    • 资助金额:
      $2.58万
    • 财政年份:
      2016
    • 负责人:
      SATO Takashi
    • 依托单位:
    Study of nanoparticles-incorporating immune modulating oligodeoxynucleotide for the treatment of lung diseases
    • 批准号:
      15K09224
    • 项目类别:
      Grant-in-Aid for Scientific Research (C)
    • 资助金额:
      $3.08万
    • 财政年份:
      2015
    • 负责人:
      SATO Takashi
    • 依托单位:
    Evolution of the new competition policy by the open source strategy
    • 批准号:
      25380313
    • 项目类别:
      Grant-in-Aid for Scientific Research (C)
    • 资助金额:
      $2.5万
    • 财政年份:
      2013
    • 负责人:
      SATO Takashi
    • 依托单位:
    Development of drugs targeting secretory inhibition of transthyretin for familial amyloidotic polyneuropathy
    • 批准号:
      24790079
    • 项目类别:
      Grant-in-Aid for Young Scientists (B)
    • 资助金额:
      $2.91万
    • 财政年份:
      2012
    • 负责人:
      SATO Takashi
    • 依托单位:
    海外基金