Study of inhaled nanoparticles incorporating synthetic oligodeoxynucleotides to treat lung diseases

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We have developed biodegradable polyketal nano-particles containing immune-modulatory oligodeoxynucleotides (PKN-ODN), that degraded as predicted under physiologic conditions. To evaluate the ability of PKN-ODN to reduce pulmonary inflammation, well established silicosis and elastase-induced emphysema mouse models were used to develop the technology for the endotracheal delivery of PKN-ODN designed for the treatment pulmonary inflammation and the subsequent monitoring of the outcome of such intervention by Flexivent pulmonary function measuring system. In murine emphysema model, single intratracheal instillation of immune-stimulatory ODN could improve the changes in lung function parameters (Resistance, Elastance, Compliance), implying a potential treatment option.