Investigation of the role of cell-cycle regulatory mechanism in hepatic glucose metabolism
Investigation of the role of cell-cycle regulatory mechanism in hepatic glucose metabolism
批准号:
21790868
负责人:
INOUE Hiroshi
金额:
$2.66万
依托单位:
依托单位国家:
日本
项目类别:
Grant-in-Aid for Young Scientists (B)
财政年份:
2009
资助国家:
日本
项目状态:
已结题
起止时间:
2009 至 2010
中文摘要
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英文摘要
Cyclin D1 is known to regulate not only cell-cycle but also activity of various transcription factors. Through this investigation, we have uncoverd an alteration in hepatic cyclin D1 expression by fasting and refeeding. Fasting reduced the expression of cyclin D1 gene and protein and refeeding increased. We have also clarified that cyclin D1 suppressed the promoter activity of gluconeogenic gene in H42E hepatoma cell. These results suggest that hepatic cyclin D1 would plays a certain role in the regulation of glucose metabolism.
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DOI:
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发表时间:
期刊:
影响因子:
--
作者:
[]
通讯作者:
STAT3依存性肝糖新生調節における小胞体ストレスの役割
内质网应激在调节STAT3依赖性肝糖异生中的作用
DOI:
--
发表时间:
2010
期刊:
影响因子:
--
作者:
[山田智子, 井上啓]
通讯作者:
井上啓
Ablation of C/EBPbeta alleviates ER stress and pancreatic beta cell failure through the GRP78 chaperone in mice.
C/EBPbeta 的消融通过 GRP78 伴侣减轻了小鼠的 ER 应激和胰腺 β 细胞衰竭。
DOI:
--
发表时间:
2010
期刊:
J. Clin. Invest. 120(1)
影响因子:
--
作者:
[Matsuda, T., Kido, Y., Nakano-Hashimoto, N., Kaisho, T., Tanaka, T., Asahara, S., Shigeyama, Y., Takeda, A., Inoue, T., Shibutani, Y., Koyanagi, M., Hosooka, T., Matsumoto, M., Inoue, H., Uchida, T., Koike, M., Uchiyama, Y., Akira, S., Kasuga, M.]
通讯作者:
M.
小胞体ストレスは脱アセチル化を介してSTAT3 依存性の肝糖新生酵素発現抑制を阻害する
内质网应激通过脱乙酰化抑制 STAT3 依赖性肝糖异生酶表达
DOI:
--
发表时间:
2010
期刊:
影响因子:
--
作者:
[Matsuda T, Kido Y, Asahara SI, Kaisho T, Tanaka T, Hashimoto N, Shigeyama Y, Takeda A, Inoue T, Shibutani Y, Koyanagi M, Hosooka T, Matsumoto M,Inoue H, Uchida T, Koike M, Uchiyama Y, Akira S, Kasuga M., Takashima M., Matsuda T., 木村久美・井上啓, 木村久美・井上啓]
通讯作者:
木村久美・井上啓
中枢神経インスリン作用による肝糖産生制御機構
中枢神经系统胰岛素作用控制肝葡萄糖产生的机制
DOI:
--
发表时间:
2011
期刊:
実験医学 29(5)
影响因子:
--
作者:
[小林正稔, 岡崎由希子, 大杉満, 植木浩二郎, 門脇孝, 井上啓]
通讯作者:
井上啓
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