Analysis for the mechanisms of NK cell invasion into the connective tissue which is elucidate for mechanism of inflammation
Analysis for the mechanisms of NK cell invasion into the connective tissue which is elucidate for mechanism of inflammation
批准号:
21791833
负责人:
INOUE Hiroshi
金额:
$2.41万
依托单位:
依托单位国家:
日本
项目类别:
Grant-in-Aid for Young Scientists (B)
财政年份:
2009
资助国家:
日本
项目状态:
已结题
起止时间:
2009 至 2010
中文摘要
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英文摘要
Natural killer (NK) cells play a key role in inflammation and tumor regression through their ability to migrate into tissues. CXCL12 is a chemokine that promotes lymphocyte invasion and migration into tissues. However, the mechanism for this process remains incompletely understood. In this study, we show that CXCL12 significantly enhanced NK cell invasion into type I collagen and increase the production of matrix metalloproteinase- 1 (MMP-1). Confocal immunofluorescence studies show that MMP-1 colocalized on NK cell surface that was stimulated by CXCL12.
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ボツリヌストキシンAの導管注入によるラット唾液腺のnNOSの免疫反応に対する影響.
导管注射A型肉毒毒素对大鼠唾液腺nNOS免疫反应的影响。
DOI:
--
发表时间:
2010
期刊:
影响因子:
--
作者:
[内橋賢二, 成瀬真弓, 藤本哲也, 平野俊一朗, 井上 博, 西川泰央.]
通讯作者:
西川泰央.
CXCL12刺激によるNK細胞のI型コラーゲンに対する浸潤と分解について.
关于CXCL12刺激的NK细胞对I型胶原蛋白的浸润和降解。
DOI:
--
发表时间:
2009
期刊:
影响因子:
--
作者:
[中島紗恵子, 井上博, 西川泰央, 松本尚之.]
通讯作者:
松本尚之.
CXCL8刺激NK細胞におけるI型コラーゲンに対する浸潤と遊走について.
CXCL8 刺激的 NK 细胞中 I 型胶原的侵袭和迁移。
DOI:
--
发表时间:
2009
期刊:
影响因子:
--
作者:
[井上博, 合田征司, 池尾隆, 堂前尚親, 西川泰央.]
通讯作者:
西川泰央.
NK細胞におけるIL-17の影響.
IL-17 对 NK 细胞的影响。
DOI:
--
发表时间:
2010
期刊:
影响因子:
--
作者:
[井上博, 藤本哲也, 成瀬真弓, 平野俊一朗, 内橋賢二, 西川泰央.]
通讯作者:
西川泰央.
Matrix metalloproteinase 1 produced by CXCL12 stimulation on NK92 cells
CXCL12 刺激 NK92 细胞产生基质金属蛋白酶 1
DOI:
--
发表时间:
2009
期刊:
J Osaka Dent Univ 43
影响因子:
--
作者:
[Asai T, Kazama R, Fukushima M, Okiji T., Toru Hayashi, INOUE H]
通讯作者:
INOUE H
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