Study on circadian changes in autonomic function in heart failure and central hypercapnic chemosensitivity
Study on circadian changes in autonomic function in heart failure and central hypercapnic chemosensitivity
批准号:
20590817
负责人:
INOUE Hiroshi
金额:
$2.91万
依托单位:
依托单位国家:
日本
项目类别:
Grant-in-Aid for Scientific Research (C)
财政年份:
2008
资助国家:
日本
项目状态:
已结题
起止时间:
2008 至 2010
中文摘要
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英文摘要
This study was designed to determine abnormal circadian variations in autonomic function in rats with heart failure. We developed an experimental system that enables continuous 24-48 hour sampling of blood pressure and heart rate in conscious, unrestrained rats. Low frequency components of diastolic blood pressure variability, an index of sympathetic tone, were higher during the awakening period than during the sleeping period. The enhanced sympathetic tone during the awakening period was related to an augmentation of central chemosensitiviy evaluated by hourly intermittent hypercapnic conditions.
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中枢性無呼吸を有する心不全患者に対するポジションセラピーの可能性
体位治疗对伴有中枢性呼吸暂停的心力衰竭患者的可能性
DOI:
--
发表时间:
2009
期刊:
影响因子:
--
作者:
[城宝秀司, 織田慶孝, 原田大輔, 平井忠和, 井上博]
通讯作者:
井上博
Sympathetic cardiorenal interaction becomes exaggerated when cardiac and renal functions are both deteriorated.
当心脏和肾功能均恶化时,交感心肾相互作用就会变得过度。
DOI:
--
发表时间:
2008
期刊:
影响因子:
--
作者:
[Oda Y, Joho S, Hirai T, Asanoi H, Inoue H]
通讯作者:
Inoue H
原因疾患からみた心不全のアプローチ-不整脈(心不全治療Skill Upマニュアル)(北風政史編)
从病因的角度看待心力衰竭 - 心律失常(心力衰竭治疗技能提升手册)(北风正志主编)
DOI:
--
发表时间:
2008
期刊:
影响因子:
--
作者:
[坂本有, 井上博]
通讯作者:
井上博
Effects of bisoprolol on sympathetic morning surge in rats with chronic heart failure.
比索洛尔对慢性心力衰竭大鼠交感神经晨峰的影响。
DOI:
--
发表时间:
2010
期刊:
影响因子:
--
作者:
[Ohori T, Hirai T, Joho S, Kameyama T, Nozawa T, Asanoi H, Inoue H.]
通讯作者:
Inoue H.
DOI:
10.1016/j.autneu.2010.01.005
发表时间:
2010-06-24
期刊:
AUTONOMIC NEUROSCIENCE-BASIC & CLINICAL
影响因子:
2.7
作者:
[Oda, Yoshitaka, Joho, Shuji, Inoue, Hiroshi]
通讯作者:
Inoue, Hiroshi
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