Study on circadian changes in sympathetic tone in subtotal nephrectomized rats with heart failure

肾大部切除心力衰竭大鼠交感神经张力昼夜变化的研究

• 批准号: 23591033
• 负责人: INOUE Hiroshi
• 金额: $ 3.33万
• 依托单位: University of Toyama
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2011
• 资助国家: 日本
• 起止时间: 2011 至 2013
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-23591033/
• 关键词: 心不全; 心腎連関; 自律神経機能; 慢性腎臓病; 交感神経機能; 化学反射感受性; 日内リズム

We studied whether chronic kidney disease (CKD) could alter circadian changes in autonomic function in rats with heart failure (HF). Rats underwent subtotal nephrectomy and surgically induced myocardial infarction as a potential model of cardiorenal syndrome. After acclimatization to a 12h light-dark cycle, blood pressure, heart rate and locomotor activity were continuously recorded for 24 - 48 hours in conscious, unrestrained rats by using instrumented radiotelemetry pressure transducer. During the awakening period, low frequency components of diastolic blood pressure variability, an index of sympathetic tone, were more exaggerated in HF rats with CKD than in HF rats without CKD. Hypercapnic chemosensitivity evaluated by hourly intermittent CO2 exposure was transiently increased during the awakening period in HF rats with CKD, suggesting that central chemosensitivity could be related to the exaggerated sympathetic tone in cardiorenal syndrome.

我们研究了慢性肾脏病（CKD）是否可以改变心力衰竭（HF）大鼠自主神经功能的昼夜变化。大鼠接受肾次全切除术和手术诱导的心肌梗死作为心肾综合征的潜在模型。大鼠在12小时的光暗环境中适应后，用无线遥测压力传感器连续记录24 - 48小时的血压、心率和自发活动。 在觉醒期间，舒张压变异性的低频成分，交感神经张力的指数，在心衰大鼠CKD比心衰大鼠没有CKD更夸张。 通过每小时间歇性CO2暴露评估的高碳酸血症化疗敏感性在HF CKD大鼠的觉醒期间短暂增加，表明中枢化疗敏感性可能与心肾综合征中过度的交感神经紧张有关。

项目成果

Sympathetic overactivation in dilated phase of hypertrophic cardiomyopathy

肥厚型心肌病扩张期交感神经过度激活

• 发表时间: 2011
• 作者: Ushijima R;Joho S;Oda Y;Harada D;Hirai T;Asanoi H;Inoue H.
• 通讯作者: Inoue H.

Enhanced sympathetic tone during the awakening period in nephrectomized rats with myocardial infarction

心肌梗死肾切除大鼠觉醒期交感神经张力增强

• 发表时间: 2013
• 作者: Hirai T;Numa S;Ohori T;Joho S;Nozawa T;Asanoi H;Inoue H.
• 通讯作者: Inoue H.

Fluvastatin-induced reduction of oxidative stress ameliorates diabetic cardiomyopathy in association with improving coronary microvasculature

• DOI: 10.1007/s00380-013-0402-6
• 发表时间: 2014-07-01
• 期刊: HEART AND VESSELS
• 影响因子: 1.5
• 作者: Shida, Takuya;Nozawa, Takashi;Inoue, Hiroshi
• 通讯作者: Inoue, Hiroshi

Enhanced sympathetic tone during the awakening period in nephrectomized rats with myocardial infarction.

患有心肌梗塞的肾切除大鼠在觉醒期间交感神经张力增强。

• 发表时间: 2013
• 作者: Hirai T;Numa S;Ohori T;Joho S;Nozawa T;Asanoi H;Inoue H.
• 通讯作者: Inoue H.

不整脈学

心律失常学

• 发表时间: 2012
• 作者: 井上博;村川裕二 編
• 通讯作者: 村川裕二 編