establish method of measurement for plasma cncentration of dexmedetomidine

右美托咪定血浆浓度测定方法的建立

• 批准号: 21791428
• 负责人: KUROSAWA Atsushi
• 金额: $ 0.58万
• 依托单位: Asahikawa Medical College
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Young Scientists (B)
• 财政年份: 2009
• 资助国家: 日本
• 起止时间: 2009 至 2010
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-21791428/
• 关键词: 麻酔学; デクスメデトミジン; 血中濃度測定; GC-MS

We established the method for measurement of plasma concentration of dexmedetomidine, a sedative medication widely used by intensive care units in Japan. We extracted dexmedetomidine with gas chromatography-negative ion chemical ionization mass spectrometry. The quantification of dexmedetomidine became possible by this method with diazepam as internal standard substance.

我们建立了右美托咪定血浆浓度的测量方法，右美托咪定是日本重症监护室广泛使用的镇静药物。采用气相色谱-负离子化学电离质谱法提取右美托咪定。该方法以地西泮为内标物，实现了右美托咪定的定量。

项目成果

Effect of the initial loading dose of dexmedetomidine on hemodynamics in pediatric patients undergoing cardiac surgery

右美托咪定初始负荷剂量对心脏手术儿科患者血流动力学的影响

• 发表时间: 2010
• 期刊: Masui. 59(3)
• 作者: Hayashi D;Kunisawa T;Kurosawa A;Nagashima M;Takahata O;Hiroshi I.
• 通讯作者: Hiroshi I.

Dexmedetomidine was safely used for sedation during spinal anesthesia in a very elderly patient.

右美托咪定被安全地用于一位老年患者脊髓麻醉期间的镇静。

• 发表时间: 2010
• 期刊: J Anesth. 24(6)
• 作者: Kunisawa T;Hanada S;Kurosawa A;Suzuki A;Takahata O;Iwasaki H.
• 通讯作者: Iwasaki H.

Importance of model fitting when a non-commercial TCI system was used : taking Kataria's parameter as an example

使用非商业TCI系统时模型拟合的重要性：以Kataria参数为例

• DOI: 10.1007/s00540-011-1096-5
• 发表时间: 2011
• 期刊: J Anesth
• 影响因子: 2.8
• 作者: Kunisawa T;Kurosawa A;Hayashi D;Suzuki A;Takahata O;Iwasaki H
• 通讯作者: Iwasaki H