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Electrophysiological analysis of opioidergic neuroprotective effect in spinal cord ischemia

Electrophysiological analysis of opioidergic neuroprotective effect in spinal cord ischemia
阿片类药物对脊髓缺血神经保护作用的电生理分析
批准号:
21791438
负责人:
HONDA Hiroyuki
金额:
$2.41万
依托单位:
依托单位国家:
日本
项目类别:
Grant-in-Aid for Young Scientists (B)
财政年份:
2009
资助国家:
日本
项目状态:
已结题
起止时间:
2009 至 2010

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中文摘要
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英文摘要
There is a possibility that perioperative administered opioids worsen paralysis caused by spinal cord ischemia. To elucidate the effects of opioids in spinal motoneurons and its significance during an ischemic insult, we conducted the electrophysiological experiments. We revealed that the opioids modulated synaptic transmission in spinal motoneurons, however, it did not exacerbate the ischemic injury. Our findings indicate that opioids administration during spinal cord ischemia should be considered as a potential component of anesthetics during aortic surgery.
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Electrophysiological analysis of vulnerability to experimental ischemia in neonatal rat spinal ventral horn neurons
新生大鼠脊髓腹角神经元实验性缺血易损性的电生理分析
DOI: --
发表时间: 2011
期刊: Neuroscience Letters 494
影响因子: --
作者: [Hiroyuki Honda, Hiroshi Baba, Tatsuro Kohno]
通讯作者: Tatsuro Kohno
ケタミンの神経保護作用
氯胺酮的神经保护作用
DOI: --
发表时间: 2009
期刊: 臨床麻酔 33巻
影响因子: --
作者: [本田博之, 河野達郎]
通讯作者: 河野達郎
Mu opioid receptor agonist modulates synaptic transmission to neonatal rat spinal ventral horn neurons but does not affect neuronal death induced by experimental ischemia
Mu阿片受体激动剂调节新生大鼠脊髓腹角神经元的突触传递,但不影响实验性缺血引起的神经元死亡
DOI: --
发表时间: 2010
期刊:
影响因子: --
作者: [Hiroyuki Honda, Hiroshi Baba, Tatsuro Kohno]
通讯作者: Tatsuro Kohno
Mu opioid receptor agonist modulates synaptic transmission to neonatal ratspinal ventral horn neurons but does not affect neuronal death induced byexperimental ischemia
Mu阿片受体激动剂调节新生大鼠脊髓腹角神经元的突触传递,但不影响实验性缺血引起的神经元死亡
DOI: --
发表时间: 2010
期刊:
影响因子: --
作者: [Hiroyuki Honda, Hiroshi Baba, Tatsuro Kohno]
通讯作者: Tatsuro Kohno
Study of documents distributed at school for foreign parents
Effects and neuroprotection of the anesthetic agent in the spinal ventral horn neuron
  • 批准号:
    26462331
  • 项目类别:
    Grant-in-Aid for Scientific Research (C)
  • 资助金额:
    $3.08万
  • 财政年份:
    2014
  • 负责人:
    HONDA Hiroyuki
  • 依托单位:
Electrophysiological analysis of anesthetic neuroprotective effect
  • 批准号:
    24791582
  • 项目类别:
    Grant-in-Aid for Young Scientists (B)
  • 资助金额:
    $2.66万
  • 财政年份:
    2012
  • 负责人:
    HONDA Hiroyuki
  • 依托单位:
The physical distribution and community of the 16th century western part of Japan
  • 批准号:
    23520814
  • 项目类别:
    Grant-in-Aid for Scientific Research (C)
  • 资助金额:
    $1.25万
  • 财政年份:
    2011
  • 负责人:
    HONDA Hiroyuki
  • 依托单位:
海外基金