Electrophysiological analysis of anesthetic neuroprotective effect

麻醉神经保护作用的电生理分析

• 批准号: 24791582
• 负责人: HONDA Hiroyuki
• 金额: $ 2.66万
• 依托单位: Niigata University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Young Scientists (B)
• 财政年份: 2012
• 资助国家: 日本
• 起止时间: 2012-04-01 至 2014-03-31
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-24791582/
• 关键词: 神経保護; 脊髄虚血; パッチクランプ; 興奮性神経細胞死; ホールセル・パッチクランプ法; 麻酔薬

One of the most worrisome complications of thoracoabdominal aneurysm repair is paraplegia caused by spinal cord ischemia. We revealed that ischemic insult induced the three-phase change of synaptic neurotransmission on spinal ventral horn neurons. The reactive oxygen species also produced similar reaction. We also elucidated that mu opioid receptor activation inhibited both the excitatory and inhibitory neurotransmission in spinal ventral horn neurons but did not influence ongoing ischemia-induced neuronal death. Our findings suggest that control of the inhibitory input to the spinal ventral horn neurons is important for neuroprotection.

胸腹部动脉瘤修复术最令人担忧的并发症之一是脊髓缺血引起的截瘫。我们揭示了缺血损伤引起脊髓腹角神经元突触传递的三相变化。活性氧也产生类似的反应。我们还阐明，μ阿片受体激活抑制脊髓腹角神经元的兴奋性和抑制性神经传递，但不影响持续缺血诱导的神经元死亡。我们的研究结果表明，抑制性输入的脊髓腹角神经元的控制是重要的神经保护。

项目成果

The mu opioid receptor activation does not affect ischemia-induced agonal currents in rat spinal ventral horn.

μ阿片受体激活不影响大鼠脊髓腹角缺血诱导的激动电流。

• DOI: 10.1007/s00540-014-1829-3
• 发表时间: 2014
• 期刊: Journal of anesthesia
• 影响因子: 2.8
• 作者: Hiroyuki Honda;Hiroshi Baba;Tatsuro Kohno
• 通讯作者: Tatsuro Kohno

The Mu Opioid Receptor Modulates Neurotransmission in the Rat Spinal Ventral Horn

• DOI: 10.1213/ane.0b013e318259393d
• 发表时间: 2012-09-01
• 期刊: ANESTHESIA AND ANALGESIA
• 影响因子: 5.7
• 作者: Honda, Hiroyuki;Kawasaki, Yasuhiko;Kohno, Tatsuro
• 通讯作者: Kohno, Tatsuro