Electrophysiological analysis of anesthetic neuroprotective effect

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One of the most worrisome complications of thoracoabdominal aneurysm repair is paraplegia caused by spinal cord ischemia. We revealed that ischemic insult induced the three-phase change of synaptic neurotransmission on spinal ventral horn neurons. The reactive oxygen species also produced similar reaction. We also elucidated that mu opioid receptor activation inhibited both the excitatory and inhibitory neurotransmission in spinal ventral horn neurons but did not influence ongoing ischemia-induced neuronal death. Our findings suggest that control of the inhibitory input to the spinal ventral horn neurons is important for neuroprotection.