Elucidation of the role of endoplasmic reticulum stress in sepsis for therapeutic development

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When stress disturbs cell homeostasis, unfolded proteins accumulated in endoplasmic reticulum. This state is called endoplasmic reticulum stress. It is observed that the expression of endoplasmic reticulum stress-related proteins, which are necessary to manage endoplasmic reticulum stress, is different in each part of pancreas or adrenal grand. Expression of those proteins increases in sepsis especially in the part where expression is normally weak. These results suggest that endoplasmic reticulum stress induced with sepsis is managed with induction of expression of endoplasmic reticulum stress-related proteins in weakly expressed part.