Relationship between VDR phenotype and sarcopenia with functional decline among the old-old Japanese people

在本研究中，维生素D受体（VDR）基因表型和肌肉质量和肌肉力量的肌肉减少症与功能下降的指标之间的关系进行了调查，从横截面和纵向方面的老年人生活在社区中。受试者为居住在东京都北方板桥区的75岁及以上的老年人，他们被邀请进行预防老年综合征和长期护理状态的集体健康检查。在集体健康检查中，测量了肌肉力量，如握力和膝关节伸展力量，周长作为肌肉减少的指标，还测量了Tendon能力指数作为功能能力的指标，结果发现VDR表型与肌肉减少和功能下降有明显的关系。特别是VDR的Fok I基因无论从横截面还是纵向观察都显示出老年人肌肉减少症和功能减退的显著危险性，我们必须考虑这些基因表型以及老年人的长期生活方式，以便在不久的将来预防肌肉减少症和功能减退。

In the present study, the relationship between Vitamin D Receptor (VDR) gene phenotype and muscle mass and muscle strength as indicators of sarcopenia with functional decline were investigated among the elderly Japanese people living in the community from both cross-sectional and longitudinal aspects. The subjects, the old -old people with age 75 year-old and above living in the Itabashi Ward, northern part of Tokyo Metropolitan area, were invited to undertake mass health examination for prevention of geriatric syndrome and long-term care state. During mass health examination, they were measured muscle power such as grip strength and knee extension power, circumference of the girth as indicators of sarcopenia and also measured TMIG Index of Competence as an indicator of functional capacity.As a result, we found a clear relationship between VDR phenotype and sarcopenia with functional decline. Particularly, Fok I of VDR showed siginificant risk for progress of sarcopenia and decline of functional capacity among the old-old people from both cross-sectional and longitudinal observations.We have to consider these gene phenotype as well as long-term life style among the elderly in order to prevent sarcopenia and functional decline in near future.