Relationship between VDR phenotype and sarcopenia with functional decline among the old-old Japanese people

日本老年人VDR表型与肌少症及功能衰退的关系

• 批准号: 20390189
• 负责人: SUZUKI Takao
• 金额: $ 11.65万
• 依托单位: Tokyo Metropolitan Institute of Gerontology
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (B)
• 财政年份: 2008
• 资助国家: 日本
• 起止时间: 2008 至 2010
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-20390189/
• 关键词: 筋肉量減少症(サルコペニア); 生活機能; VDR遺伝子多型; 後期高齢者; ビタミンD受容体遺伝子; 高齢者; サルコペニア; 要介護; 筋肉量減少症

In the present study, the relationship between Vitamin D Receptor (VDR) gene phenotype and muscle mass and muscle strength as indicators of sarcopenia with functional decline were investigated among the elderly Japanese people living in the community from both cross-sectional and longitudinal aspects. The subjects, the old -old people with age 75 year-old and above living in the Itabashi Ward, northern part of Tokyo Metropolitan area, were invited to undertake mass health examination for prevention of geriatric syndrome and long-term care state. During mass health examination, they were measured muscle power such as grip strength and knee extension power, circumference of the girth as indicators of sarcopenia and also measured TMIG Index of Competence as an indicator of functional capacity.As a result, we found a clear relationship between VDR phenotype and sarcopenia with functional decline. Particularly, Fok I of VDR showed siginificant risk for progress of sarcopenia and decline of functional capacity among the old-old people from both cross-sectional and longitudinal observations.We have to consider these gene phenotype as well as long-term life style among the elderly in order to prevent sarcopenia and functional decline in near future.

本研究从横断面和纵向两个方面探讨了维生素D受体(VDR)基因表型与肌肉质量和肌力之间的关系，并探讨了VDR基因表型与肌肉量和肌力的关系。受试者为居住在东京都北部板桥区75岁及以上的老年人，为预防老年综合征和长期护理状态，邀请他们进行集体健康检查。在大规模健康体检中，测量肌肉力量，如握力和伸膝力，腰围作为骨量减少的指标，并测量TMIG能力指数作为功能能力的指标。结果，我们发现VDR表型与骨量减少有明显的关系。特别是VDR的Fok I，无论是从横断面还是纵向观察，都显示出老年人发生骨质疏松症进展和功能能力下降的显著风险，我们必须考虑这些基因表型和老年人的长期生活方式，以便在不久的将来预防骨质疏松症和功能衰退。

项目成果

Association between C-reactive protein (CRP) level and physical performance in community-dwelling elderly in Japan

• DOI: 10.1016/j.archger.2009.10.002
• 发表时间: 2010-09-01
• 期刊: ARCHIVES OF GERONTOLOGY AND GERIATRICS
• 影响因子: 4
• 作者: Yoshida, Yuko;Iwasa, Hajime;Suzuki, Takao
• 通讯作者: Suzuki, Takao

ビタミンDの転倒予防効果

维生素D的预防跌倒作用

• 发表时间: 2010
• 期刊: 骨粗鬆症治療 8
• 作者: Hayashi T (2番目/7);Sato KK (3番目/7);Endo G (6番目/7);鈴木隆雄
• 通讯作者: 鈴木隆雄

高齢者を対象とした骨粗鬆症検診

老年人骨质疏松症筛查

• 发表时间: 2009
• 作者: Yoshimura N;Muraki S;Oka H;Mabuchi A;Kinoshita H;Yoshida M;Kawaguchi H;Nakamura K;Akune T;鈴木隆雄
• 通讯作者: 鈴木隆雄

高齢期における生活習慣変容の意義と限界-生活習慣病予防と介護予防の戦略を考える-

老年生活方式改变的意义和局限性 - 关于生活方式相关疾病的预防策略和护理的思考 -

• 发表时间: 2010
• 期刊: 日本臨床 68
• 作者: Wakai K;Hamajima N;kita Y;et al;鈴木隆雄
• 通讯作者: 鈴木隆雄

The effects of multidimensional exercise on functional decline, urinary incontinence, and fear of falling in community-dwelling elderly women. A randomized controlled and 6-month follow-up trial.

多维运动对社区老年女性功能衰退、尿失禁和跌倒恐惧的影响。

• 发表时间: 2011
• 期刊: Arch.Gerontol.Geriat.
• 作者: Kim H;Yoshida H;Suzuki T
• 通讯作者: Suzuki T