Early diagnosis of the possibility of severe sepsis using NMR

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After extracting the removed brains and performing NMR measurement of the extracts, NMR data were analized. We found that 3 groups of L P S (10 mg / kg/day and 2 mg / kg) and saline treated were isolated in 6 hours after administration. No rats died within 6 hours. This finding suggests the possibility of identification of sepsis and its severity in the brain of early sepsis by this method. Although this finding is from ex vivo experiment, we consider it is important knowledge leading to early diagnosis of the possibility of severe sepsis with in vivo MRS sinse brain has less movement and it is very suitable for in vivo MRS measurement.