Early diagnosis of the possibility of severe sepsis using NMR

使用 NMR 早期诊断严重败血症的可能性

• 批准号: 23592668
• 负责人: SUZUKI Takao
• 金额: $ 3.41万
• 依托单位: Kyoto University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2011
• 资助国家: 日本
• 起止时间: 2011 至 2013
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-23592668/
• 关键词: 集中治療医学; 集中治療; 敗血症; 核磁気共鳴; 重症度診断; 脳

After extracting the removed brains and performing NMR measurement of the extracts, NMR data were analized. We found that 3 groups of L P S (10 mg / kg/day and 2 mg / kg) and saline treated were isolated in 6 hours after administration. No rats died within 6 hours. This finding suggests the possibility of identification of sepsis and its severity in the brain of early sepsis by this method. Although this finding is from ex vivo experiment, we consider it is important knowledge leading to early diagnosis of the possibility of severe sepsis with in vivo MRS sinse brain has less movement and it is very suitable for in vivo MRS measurement.

在提取大脑并对提取物进行核磁共振测量后，对核磁共振数据进行分析。结果发现，L P S(10 mg/kg/d、2 mg/kg/d)组和生理盐水组在给药后6h内均分离出大鼠模型。6小时内无大鼠死亡。这一发现表明，用这种方法可以在早期脓毒症的大脑中识别脓毒症及其严重程度。虽然这一发现来自于体外实验，但我们认为这是导致早期诊断严重脓毒症可能性的重要知识，体内MRS脑活动较少，非常适合体内MRS测量。