Shh signaling is related to Bmp signaling in ameloblast differentiation and tooth reconstruction

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Tooth development is regulated by various intercellular signaling molecules, such as sonic hedgehog (Shh), bone morphogenetic proteins (BMPs), Wnts and fibloblasts growth factors. These molecules are also essential for ameloblast differentiation. We reported that Shh signaling was indispensable for ameloblast development. In ameloblast, Shh, BMPs and Wnts expressions are observed in their early stage of development, along with their receptor molecules. These observations suggest the involvement of Shh, BMPs and Wnts signaling in the differentiation of ameloblasts. We revealed that Shh induced the expression of BMPs and Wnts, suggesting that Shh may play a central role to activate the signaling network in ameloblasts.