Effects of food components on circadian rhythms

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I examined effects of food components on circadian rhythms in mice. First, I revealed that caffeine intake lengthens circadian locomotor activities in mice, and also that caffeine intake delays circadian clock in the liver. Second, I clarified that the liver clock requires both glucose and amino acids to be entrained by food in mice, and Per2 and Dec1 clock genes play an important role in the food entrainment. Finally, I found that a sodium dependent glucose transporter Sglt1 is indispensable in advance of peripheral clocks by consuming high-salt diet in mice.