The radioresistance mechanism by neurosphere as a cancer stem cell model cell

为了阐明神经干细胞在肿瘤发生过程中导致肿瘤干细胞的发生，本研究试图在体内观察含有神经干细胞的神经球是否转化为与肿瘤发生相关的肿瘤干细胞。每隔10天培养一次，其生长速率维持得更好。似乎分裂的次数超过100次，然后形成不朽的细胞。对该永生细胞进行染色体分析的结果表明，虽然核型的不稳定主要见于细胞，但在某些细胞中，核型两次保持正常。

To elucidate that neural stem cells result in cancer stem cell during tumorigenesis, in this study, it is tried that whether the neurosphere (containing neural stem cell) transform to malignants relevant to tumorigenesis in vivo. When it cultured per 10 days, it came to maintain the growth ratio more. It seems that the number of divisions is over 100 times, and then formed into immortal cells. As a result of the chromosome analysis of this immortal cells, although the instability of the karyotype was mainly seen in cells, in some cells, the karyotype was maintained normal twice.