Basic study of evaluation system in vascular diseases

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The basic study of CL-P1 and CL-K1 has been performed by using recombinant collectins and gene-modified mice. Both established recombinant collectins could produce their antibodies, which were used for the development of ELISA system and evaluation of tissue expressions in those mice and human. The knock-out mice with CL-P1 and CL-K1 have been established. CL-K1 KO mice were analyzed using above antibodies. The prototype ELISA system for the evaluation of its blood concentration was established. The CL-P1 KO and TG mice have been established and their complementation experiments have been performed.