Sulcal neuroanatomy of human brain

我们对中央沟进行了三维神经解剖学分析。使用自动沟检测软件从MR图像中勾画出中央沟的形状。中央沟前壁左侧的手钮突出和表面积明显较大。手的最内侧部分在轴向MR图像中是稳定的，这意味着它可以作为局部坐标系的原点。我们将此技术应用于颅内电极片的制造。建立了一种脑表面自动检测、3D CAD模具设计、3D打印机模具快速制造、脑表面硅胶电极片贴合的制造方法。本文将该方法制作的高密度三维电极阵列用于一名渐冻症患者的脑机接口临床研究。

We performed 3 dimensional neuroanatomical analyses of the central sulcus. The shape of the central sulcus was delineated from MR images using automatic sulcus detection software. Protrusion and surface area of the hand knob was significantly larger in the left side of the anterior wall of the central sulcus. The most medial portion of the hand area was stable in the axial MR images, which was meant to be useful as the origin of the local coordinate system. We applied this technique to intracranial electrode sheet manufacturing. We established a manufacturing method of automatic brain surface detection, mold design using 3D CAD, rapid manufacturing of the mold using a 3D printer, and manufacturing silicone electrode sheet fitting to individual brain surfaces. A high density 3D electrode array made using this method was used for an ALS patient in our clinical research of brain machine interfaces.