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Non invasive 3-demensional measurement of brain function with developed synthetic aperture magnetometry

利用先进的合成孔径磁力测量技术对脑功能进行无创三维测量

基本信息

批准号：
11470290
负责人：
YOSHIMINE Toshiki
金额：
$ 8.51万
依托单位：
Osaka University
依托单位国家：
日本
项目类别：
Grant-in-Aid for Scientific Research (B).
财政年份：
1999
资助国家：
日本
起止时间：
1999 至 2000
项目状态：
已结题

项目摘要

The equivalent current dipole (ECD) method conventionally used for analysis for magnetoencephalography represent the activated brain area as one or small number of dipoles. It is not enough for comprehensive understanding of the brain activity, since the functional process of the brain is derived from the activation of neurons in a certain volume of cortex and ECD only displays the center of gravity of activated brain as a representative single point. We applied recently developed synthetic aperture magnetometry (SAM) with a spatially-selective beamformer, which filters out the background brain noise from other regions to obtain the meaningful signals from the arbitrary target regions. The neuromagnetic signals are transformed into units of dipole moment on a per voxel basis ; this enables one to measure the current density of the small portion of the brain with an enhanced sensitivity (SAM virtual sensor method). With further application of statistical imaging technique, statistical d … More ifference in the power of selected frequency band can be evaluated between the active and control states. Those areas with statistical difference can be displayed on the individual MRI in a tomographic manner (SAM statistical method). In this study, following neuro-functional processes were analyzed. Owing to the superior spatial resolution of the MEG and to the novel filtering technique of SAM, the tomography of neuromagnetic event related synchronization (ERS) or desynchronization (ERD) evoked by neurological task was demonstrated for the whole brain.1. Motor-related brain activityThe influence of the hemispheric dominance as well as hand dominance wasdisclosed.2. Sensory-related brain activitySimultaneous and multifocal brain activations with very high frequency oscillation were disclosed.3. Language-related brain activityBoth sensory and motor language area were demonstrated with reading without phonation task.4. EpilepsyThe SAM virtual sensor method demonstrated the origin and the propagation process of epileptic discharges as if the intracranial electrodes were implanted. The elimination of invasive monitoring was implied. Less

传统上用于脑磁图分析的等效电流偶极子（ECD）方法将激活的大脑区域表示为一个或少量的偶极子。对于大脑活动的全面了解是不够的，因为大脑的功能过程来源于一定体积的皮层中神经元的激活，而ECD仅将激活的大脑的重心显示为具有代表性的单点。我们应用了最近开发的带有空间选择性波束形成器的合成孔径磁力测量（SAM），它可以滤除来自其他区域的背景大脑噪声，从而从任意目标区域获取有意义的信号。神经磁信号在每个体素的基础上转换为偶极矩单位；这使得人们能够以更高的灵敏度测量大脑一小部分的电流密度（SAM 虚拟传感器方法）。随着统计成像技术的进一步应用，可以评估活动状态和控制状态之间所选频带功率的统计差异。具有统计差异的区域可以通过断层扫描方式（SAM统计方法）显示在个体MRI上。在这项研究中，分析了以下神经功能过程。由于MEG的优越空间分辨率和SAM的新颖过滤技术，神经任务引起的神经磁事件相关同步（ERS）或去同步（ERD）的断层扫描被证明是针对整个大脑的。 1．运动相关的大脑活动揭示了半球优势和手优势的影响。 2．与感觉相关的大脑活动公开了具有非常高频率振荡的同时和多焦点大脑激活。 3．语言相关的大脑活动通过无发声任务的阅读来展示感觉和运动语言区。 4．癫痫SAM虚拟传感器方法如同植入颅内电极一样演示了癫痫放电的起源和传播过程。这意味着消除侵入性监测。较少的