Restoration of the visual function by electrical stimulation to the neural column

通过电刺激神经柱恢复视觉功能

• 批准号: 15300202
• 负责人: YOSHIMINE Toshiki
• 金额: $ 8.7万
• 依托单位: Osaka University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (B)
• 财政年份: 2003
• 资助国家: 日本
• 起止时间: 2003 至 2005
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-15300202/
• 关键词: visual restoration; electrical stimulation; visual prosthesis; transcranial magnetic stimulation; magnetoencephalography; 人工視覚; 視覚障害; 開口合成法

1.Behavioral changes during electrical stimulation on the rat visual cortexA blind rat model was made by resecting bilateral optic nerves. A needle electrode was inserted in the IV layer of the visual cortex. Exploring behavior was decreased by electrical stimulation to the visual cortex but not to the sensorimotor cortex. These results suggested that the electrical stimulation to the visual cortex acts as sensory stimulation2.Electrical stimulation and recording from a micro-multielectrode using ratsPhotic retinal stimulation and electrical cortical stimulation were compared during recording the rat's visual cortex using a micro-multielectrode. Single pulse electrical stimulation to the primary visual cortex evoked the spikes around the visual cortex Joint PSTH analyses revealed that the functional connectivity between the evoked spikes had partial similarity in spatial distribution between photic stimulation and electrical stimulation3.Visual sensation induced by occipital transcrani … More al magnetic stimulation (TMS)TMS to the occipital cortex was performed for healthy subjects and patients with severe visual disturbance. Induced visual sensation was measured quantitatively. Single or repetitive stimuli were delivered. In healthy subjects, visual sensations were consistently induced by repetitive TMS, and their locations and characteristics were well concordant with basic neuro-anatomical findings. Further investigation would be needed to apply this method to the indication of cortical visual prosthesis4.Synthetic aperture magnetometry (SAM) of the visual cortexTo establish the evaluation of the cerebral visual function, local oscillatory changes induced by wide-visual-angle pattern reversal stimulation using SAM for healthy subjects and patients with visual disturbance. Optimal stimulation in quadrant field stimulation was also investigated. Gamma synchronization and alpha/beta desynchronization were consistently demonstrated in the visual cortex in healthy subjects, whereas the location and frequency of the peak oscillatory changes were sensitively shifted due to the lesion. Further improvement would be needed to establish quadrant field stimulation Less

1.电刺激大鼠视皮层时的行为学变化采用切除双侧视神经的方法建立大鼠盲态模型。将针电极插入视觉皮层的IV层。探索行为减少了电刺激的视觉皮层，但不感觉运动皮层。2.微多电极电刺激和记录的实验研究比较了视网膜光刺激和皮层电刺激在微多电极记录大鼠视皮层过程中的作用。单脉冲电刺激初级视皮层诱发视皮层周围的棘波。联合PSTH分析显示，光刺激和电刺激诱发的棘波之间的功能连接在空间分布上具有部分相似性。 ...更多信息 对健康受试者和严重视力障碍患者进行枕叶皮层磁刺激（TMS）。定量测量诱导的视觉感觉。提供单一或重复刺激。在健康受试者中，视觉感觉一致地由重复TMS诱导，并且其位置和特征与基本神经解剖学结果一致。4.视觉皮层的合成孔径磁测量（SAM）建立了对健康受试者和视觉障碍患者的脑视觉功能、宽视角模式反转刺激引起的局部振荡变化的评估。并对象限场刺激中的最佳刺激进行了研究。健康受试者的视觉皮层中始终显示出伽马同步和α/β去同步化，而峰值振荡变化的位置和频率由于病变而敏感地转移。需要进一步改进以建立象限场刺激减

项目成果

機能的大脳半球切除術

功能性大脑半球切除术

• 发表时间: 2006
• 期刊: 脳神経外科ジャーナル 15・3
• 作者: 加藤;天美
• 通讯作者: 天美

難治性疼痛に対する脳皮質刺激療法

脑皮质刺激疗法治疗顽固性疼痛

• 发表时间: 2003
• 期刊: 脳神経外科速報 13
• 作者: Youichi Saitoh;富永 篤;有田 和徳;Kato Amami;Eguchi Yutaka;Arita K;Saitoh Y;富永 篤;Saitoh Y;Tomishima T;有田 和徳;Yenomas DC;Soichi Obara;Kanou Y;二宮宏智;Arita K;Hideo Takeshima;Tomoaki Goto;齋藤洋一
• 通讯作者: 齋藤洋一

視覚課題への注意が体性感覚処理に及ぼす影響

视觉任务注意力对体感处理的影响

• 发表时间: 2005
• 期刊: 臨床脳波 47・7
• 作者: Miyanari A;Hirayama A;加藤天美;Miyanari A;Hirayama A;Kinoshita M;Fujimoto Y;Kato A;Taniguchi M;高橋優
• 通讯作者: 高橋優

インターフェイス装置、インターフェイス方法及びその装置を用いた制御訓練装置

接口装置、接口方法以及使用该装置的控制训练装置

• 发表时间: 2004

Fiber-tracking does not accurately estimate size of fiber bundle in pathological condition: initial neurosurgical experience using neuronavigation and subcortical white matter stimulation

• DOI: 10.1016/j.neuroimage.2004.07.076
• 发表时间: 2005-04-01
• 期刊: NEUROIMAGE
• 影响因子: 5.7
• 作者: Kinoshita, M;Yamada, K;Yoshimine, T
• 通讯作者: Yoshimine, T