Regulation of chondrocyte differentiation through G protein signal

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PTHrP signal through both G alpha s and G alpha q play important roles in regulation of chondrocyte differentiation, although a precise mechanism is not clear. In this study, we have tried to establish mouse model of both overexpression of either G alpha s or G alpha q in chondrocyte and also establish conditional knock-out mice of either G alpha s or G alpha q in chondrocytes to explore the specific roles of G alpha s and G alpha q in chondrocytes. Moreover, we have explored to find any proteins that interact directly with PTHrP receptor or downstream of its signal and examined any involvement in chondrocyte differentiation.