Study of the head and neck organ regeneration technology using iPS cells

本研究的目的是建立一种诱导多能干细胞向头颈部组织分化的技术，以实现头颈部器官的再生。将诱导多能干细胞分化成软骨细胞的支架植入气管缺损动物模型。组织学上证实了软骨组织的再生。诱导多能干细胞的胚状体也可再生上皮样组织。这是首次证明iPS细胞在头颈部组织再生方面的潜力的研究。

The purpose of this study is to establish a technique for differentiation from iPS cells into head and neck tissues in order to regenerate head and neck organs. The scaffold involving chondrogenic cells which were differentiated from iPS cells was implanted into the tracheal defect of animal models. Regeneration of the cartilage tissue was histologically recognized. Regeneration of the epithelial-like tissue was also recognized through embryoid bodiesfrom iPS cells. This is the first study to demonstrate the potential of iPS cells for the regeneration of the head and neck tissues.