Study of the head and neck organ regeneration technology using iPS cells

iPS细胞头颈器官再生技术研究

• 批准号: 22390317
• 负责人: OMORI Koichi
• 金额: $ 11.98万
• 依托单位: Fukushima Medical University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (B)
• 财政年份: 2010
• 资助国家: 日本
• 起止时间: 2010 至 2012
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-22390317/
• 关键词: 頭頸部外科学; 再生医学; iPS 細胞; 再生; iPS細胞; 頭頸部; 分化誘導; 再生医療

The purpose of this study is to establish a technique for differentiation from iPS cells into head and neck tissues in order to regenerate head and neck organs. The scaffold involving chondrogenic cells which were differentiated from iPS cells was implanted into the tracheal defect of animal models. Regeneration of the cartilage tissue was histologically recognized. Regeneration of the epithelial-like tissue was also recognized through embryoid bodiesfrom iPS cells. This is the first study to demonstrate the potential of iPS cells for the regeneration of the head and neck tissues.

本研究的目的是建立从iPS细胞分化为头颈部组织的技术，以再生头颈部器官。将诱导多能干细胞分化成软骨细胞的支架植入动物模型气管缺损处。组织学上确认软骨组织再生。上皮样组织的再生也被认为是通过胚状体从iPS细胞。这是第一项证明iPS细胞在头颈部组织再生中的潜力的研究。

项目成果

Potential of Induced Pluripotent Stem Cells for the Regeneration of the Tracheal Wall

• DOI: 10.1177/000348941011901009
• 发表时间: 2010-10-01
• 期刊: ANNALS OF OTOLOGY RHINOLOGY AND LARYNGOLOGY
• 影响因子: 1.4
• 作者: Imaizumi, Mitsuyoshi;Nomoto, Yukio;Omori, Koichi
• 通讯作者: Omori, Koichi

Potential of induced pluripotent stem cells for regeneration of the tracheal wall

诱导多能干细胞用于气管壁再生的潜力

• 发表时间: 2012
• 作者: Omori K;Imaizumi M;et al.
• 通讯作者: et al.

iPS 細胞移植による気管欠損部の組織再生:フローサイトメーター(FACS)による細胞解析と奇形腫形成

通过 iPS 细胞移植实现气管缺损的组织再生：使用流式细胞仪 (FACS) 进行细胞分析和畸胎瘤形成

• 发表时间: 2011
• 作者: 今泉光雅;大森孝一;他
• 通讯作者: 他

Evaluation of the Use of Induced Pluripotent Stem Cells (iPSCs) for the Regeneration of Tracheal Cartilage

• DOI: 10.3727/096368912x653147
• 发表时间: 2013-01-01
• 期刊: CELL TRANSPLANTATION
• 影响因子: 3.3
• 作者: Imaizumi, Mitsuyoshi;Nomoto, Yukio;Omori, Koichi
• 通讯作者: Omori, Koichi

気管の再生医療

气管再生医学

• 发表时间: 2012
• 作者: Otsuki K;Omori K;et al.;大森 孝一
• 通讯作者: 大森 孝一