Application of focal brain cooling for intractable epilepsy

局灶性脑冷却在顽固性癫痫中的应用

• 批准号: 22390276
• 负责人: SUZUKI Michiyasu
• 金额: $ 12.4万
• 依托单位: Yamaguchi University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (B)
• 财政年份: 2010
• 资助国家: 日本
• 起止时间: 2010 至 2012
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-22390276/
• 关键词: epilepsy; focal brain cooling; brain cooling; device; glutamate; cerebral blood flow; metabolism; 機能脳神経外科学; 脳低温; 脳低温療法

Safeness of focal brain cooling (FBC) for intractable epilepsy was verified. A rat epilepsy model was treated by the FBC. The optimal temperature to interrupt seizure without deteriorating neuronal function was 15 ℃. The FBC was applied at epilepsy surgery in human. Increased levels of glutamate and lactate reduced at 15 ℃. The FBC effectively inhibit neuronal excitotoxicity and anaerobic metabolism. Newly developed cooling device was successfully applied to cats and monkeys.

证实局灶性脑冷却（FBC）治疗难治性癫痫的安全性。用FBC治疗大鼠癫痫模型。在不损害神经元功能的情况下，中断癫痫发作的最佳温度为15℃。FBC应用于人类癫痫手术。升高的谷氨酸和乳酸水平在15℃时降低。FBC有效抑制神经元兴奋性毒性和无氧代谢。新开发的冷却装置成功地应用于猫和猴子身上。

项目成果

Insular psammomatous meningioma presenting intractable complex partial seizures.

岛叶砂粒细胞性脑膜瘤呈现顽固性复杂部分性癫痫发作。

• 发表时间: 2012
• 期刊: No Shinkei Geka
• 作者: Imoto H;Fujii M ;Nomura S ;Suzuki M;他
• 通讯作者: 他

Alterative treatment of intractable epilepsy with focal brain cooling -A review of our past studies

局灶性脑冷却替代治疗顽固性癫痫——我们过去研究的回顾

• 发表时间: 2011
• 作者: Masami Fujii;Takao Inoue;Yeting He;Yuichi Maruta;Hirochika Imoto;Hiroyasu Koizumi;Sadahiro Nomura;Tatsuji Tokiwa;Satoshi Ishizuka;Takeshi Yamakawa;Toshitaka Yamakawa
• 通讯作者: Toshitaka Yamakawa

Focal brain cooling terminates the faster frequency components of epileptic discharges induced by penicillin G in anesthetized rats

• DOI: 10.1016/j.clinph.2012.02.074
• 发表时间: 2012-09-01
• 期刊: CLINICAL NEUROPHYSIOLOGY
• 影响因子: 4.7
• 作者: Kida, Hiroyuki;Fujii, Masami;Suzuki, Michiyasu
• 通讯作者: Suzuki, Michiyasu

Inhibitory effects of focal brain cooling for motor cortical seizures in cats and nonhuman primates

局灶性脑冷却对猫和非人灵长类动物运动皮质癫痫发作的抑制作用

• 发表时间: 2011
• 作者: Takao Inoue;Yeting He;Masami Fujii;Hiroshi Fujioka;Tatsuji Tokiwa;Hiroyuki Kida;Hirochika Imoto;Yuichi Maruta;Sadahiro Nomura;Takeshi Yamakawa;Michiyasu Suzuki
• 通讯作者: Michiyasu Suzuki

脳冷却プローブを用いた術中脳機能マッピング法の確立

利用脑冷却探针建立术中脑功能图谱方法

• 发表时间: 2011
• 作者: S.Nishiyama;K.Miyake;藤井正美
• 通讯作者: 藤井正美