Application of focal brain cooling for intractable epilepsy
局灶性脑冷却在顽固性癫痫中的应用
基本信息
- 批准号:22390276
- 负责人:
- 金额:$ 12.4万
- 依托单位:
- 依托单位国家:日本
- 项目类别:Grant-in-Aid for Scientific Research (B)
- 财政年份:2010
- 资助国家:日本
- 起止时间:2010 至 2012
- 项目状态:已结题
- 来源:
- 关键词:
项目摘要
Safeness of focal brain cooling (FBC) for intractable epilepsy was verified. A rat epilepsy model was treated by the FBC. The optimal temperature to interrupt seizure without deteriorating neuronal function was 15 ℃. The FBC was applied at epilepsy surgery in human. Increased levels of glutamate and lactate reduced at 15 ℃. The FBC effectively inhibit neuronal excitotoxicity and anaerobic metabolism. Newly developed cooling device was successfully applied to cats and monkeys.
局灶性脑冷却(FBC)治疗顽固性癫痫的安全性得到验证。采用 FBC 治疗大鼠癫痫模型。在不损害神经元功能的情况下中断癫痫发作的最佳温度是15℃。 FBC被应用于人类癫痫手术。 15℃时谷氨酸含量增加,乳酸含量降低。 FBC有效抑制神经元兴奋性毒性和无氧代谢。新开发的降温装置成功应用于猫和猴子身上。
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
Insular psammomatous meningioma presenting intractable complex partial seizures.
岛叶砂粒细胞性脑膜瘤呈现顽固性复杂部分性癫痫发作。
- DOI:
- 发表时间:2012
- 期刊:
- 影响因子:0
- 作者:Imoto H;Fujii M ;Nomura S ;Suzuki M;他
- 通讯作者:他
Alterative treatment of intractable epilepsy with focal brain cooling -A review of our past studies
局灶性脑冷却替代治疗顽固性癫痫——我们过去研究的回顾
- DOI:
- 发表时间:2011
- 期刊:
- 影响因子:0
- 作者:Masami Fujii;Takao Inoue;Yeting He;Yuichi Maruta;Hirochika Imoto;Hiroyasu Koizumi;Sadahiro Nomura;Tatsuji Tokiwa;Satoshi Ishizuka;Takeshi Yamakawa;Toshitaka Yamakawa
- 通讯作者:Toshitaka Yamakawa
Focal brain cooling terminates the faster frequency components of epileptic discharges induced by penicillin G in anesthetized rats
- DOI:10.1016/j.clinph.2012.02.074
- 发表时间:2012-09-01
- 期刊:
- 影响因子:4.7
- 作者:Kida, Hiroyuki;Fujii, Masami;Suzuki, Michiyasu
- 通讯作者:Suzuki, Michiyasu
Inhibitory effects of focal brain cooling for motor cortical seizures in cats and nonhuman primates
局灶性脑冷却对猫和非人灵长类动物运动皮质癫痫发作的抑制作用
- DOI:
- 发表时间:2011
- 期刊:
- 影响因子:0
- 作者:Takao Inoue;Yeting He;Masami Fujii;Hiroshi Fujioka;Tatsuji Tokiwa;Hiroyuki Kida;Hirochika Imoto;Yuichi Maruta;Sadahiro Nomura;Takeshi Yamakawa;Michiyasu Suzuki
- 通讯作者:Michiyasu Suzuki
脳冷却プローブを用いた術中脳機能マッピング法の確立
利用脑冷却探针建立术中脑功能图谱方法
- DOI:
- 发表时间:2011
- 期刊:
- 影响因子:0
- 作者:S.Nishiyama;K.Miyake;藤井正美
- 通讯作者:藤井正美
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SUZUKI Michiyasu其他文献
SUZUKI Michiyasu的其他文献
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{{ truncateString('SUZUKI Michiyasu', 18)}}的其他基金
Protective effects of Focal brain cooling on cortical spreading depolarization in rats
局部脑冷却对大鼠皮质扩散去极化的保护作用
- 批准号:
16K15646 - 财政年份:2016
- 资助金额:
$ 12.4万 - 项目类别:
Grant-in-Aid for Challenging Exploratory Research
Evaluation and control of epilepsy dynamics based on multimodal brain signals and thermal neuromodulation using focal brain cooling
基于多模式脑信号和局灶性脑冷却热神经调节的癫痫动力学评估和控制
- 批准号:
15H05719 - 财政年份:2015
- 资助金额:
$ 12.4万 - 项目类别:
Grant-in-Aid for Scientific Research (S)
Experimental and theoretical investigations on effects of focal brain cooling on the generalized seizures
局灶性脑冷却对全身性癫痫发作影响的实验和理论研究
- 批准号:
25540136 - 财政年份:2013
- 资助金额:
$ 12.4万 - 项目类别:
Grant-in-Aid for Challenging Exploratory Research
Development of drug delivery system for central nervous system disease using with temperature control devise
使用温度控制装置的中枢神经系统疾病药物输送系统的开发
- 批准号:
22659261 - 财政年份:2010
- 资助金额:
$ 12.4万 - 项目类别:
Grant-in-Aid for Challenging Exploratory Research
Elucidation and control of cerebral neurophysiological function with focal brain-cooling for the purpose of clinical application.
以临床应用为目的,通过局灶性脑冷却来阐明和控制脑神经生理功能。
- 批准号:
19390380 - 财政年份:2007
- 资助金额:
$ 12.4万 - 项目类别:
Grant-in-Aid for Scientific Research (B)
Neurotoxic effects of exogenous tissue-type plasminogen activator on the normal brain
外源性组织型纤溶酶原激活剂对正常脑的神经毒性作用
- 批准号:
14571313 - 财政年份:2002
- 资助金额:
$ 12.4万 - 项目类别:
Grant-in-Aid for Scientific Research (C)
Effect of thrombin in the injury, especially on chemotaxis and accumulation of the inflammatory cells
凝血酶在损伤中的作用,特别是对炎症细胞趋化和积累的作用
- 批准号:
11671382 - 财政年份:1999
- 资助金额:
$ 12.4万 - 项目类别:
Grant-in-Aid for Scientific Research (C)
相似海外基金
Elucidation of molecular mechanism for focal brain cooling using transient receptor potential (TRP) channels
使用瞬时受体电位(TRP)通道阐明局灶性脑冷却的分子机制
- 批准号:
17K10830 - 财政年份:2017
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Protective effects of Focal brain cooling on cortical spreading depolarization in rats
局部脑冷却对大鼠皮质扩散去极化的保护作用
- 批准号:
16K15646 - 财政年份:2016
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Development of focal brain cooling techniques for severe head injury
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15K19971 - 财政年份:2015
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Evaluation and control of epilepsy dynamics based on multimodal brain signals and thermal neuromodulation using focal brain cooling
基于多模式脑信号和局灶性脑冷却热神经调节的癫痫动力学评估和控制
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15H05719 - 财政年份:2015
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$ 12.4万 - 项目类别:
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局灶性脑冷却对全身性癫痫发作影响的实验和理论研究
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Development of Closed-loop Implantable Focal Brain Cooling System for non-human primates
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