Study on the development and validation of behavioral intervention therapy program for psychiatric symptoms in dementia

在痴呆患者中经常观察到激动行为，并可能对照顾者造成严重的痛苦。然而，几乎没有证据表明非药物干预对痴呆患者的激越行为有效。目前的试点研究的目的是评估行为管理技术（BMT）程序开发的西雅图协议在日本的患者激动的行为。18名痴呆患者（阿尔茨海默病，n = 14;路易体痴呆，n = 4）参加了一项开放性研究，测试BMT计划的有效性。干预包括在三个月的过程中进行的20次会议。主要结局是使用痴呆激越行为量表（ABID）和Cohen-Mansfield激越量表（CMAI）测量的痴呆激越严重程度。BMT项目导致ABID和CMAI的总分显著降低。虽然ABID的身体激动行为评分和言语激动行为评分都有显著改善，但精神病症状在干预后没有改善。BMT计划可能对因激动行为而遭受痛苦的照顾者有益。在未来，需要一个精心设计的研究，以更充分地发展BMT计划。

Agitated behaviors are frequently observed in patients with dementia and can cause severe distress to caregivers. However, little evidence of the efficacy of nonpharmacological interventions for agitated behaviors exists in patients with dementia. The present pilot study aimed to evaluate the behavioral management technique (BMT) program developed by the Seattle Protocols for patients with agitated behaviors in Japan. Eighteen patients with dementia (Alzheimer’s disease, n = 14; dementia with Lewy bodies, n = 4) participated in an open study testing the effectiveness of the BMT program. The intervention consisted of 20 sessions over the course of three months. The primary outcomes were severity of agitation in dementia as measured using the Agitated Behavior in Dementia scale (ABID) and the Cohen-Mansfield Agitation Inventory (CMAI). The BMT program resulted in significant reductions in the total scores of both the ABID and CMAI. Although both the physically agitated behavior scores and the verbally agitated behavior scores of the ABID improved significantly, the psychosis symptoms did not improve after intervention. The BMT program is likely to be beneficial to caregivers suffering from distress as a result of agitated behaviors. In the future, a well-designed study to develop the BMT program more fully is needed.