Analysis of a novel signaling pathway which links G0 to M phases via centrosomal kinases

染色体不稳定性（CIN）是肿瘤恶性的基本性质之一，与异常中心体扩增和有丝分裂（M期）检查点控制紊乱相关，表明某些中心体激酶引起CIN的诱导。此外，由于不能进入G 0期而导致的异常细胞生长是癌症的另一个重要特征。在这项研究中，我们证明了中心体激酶Lats 1和Lats 2通过中心体完整性和染色体分离控制有丝分裂检查点，并防止异常细胞生长。这些结果表明，Lats 1/2激酶包括一个新的信号通路，连接G 0至M期的细胞周期。

Chromosomal instability (CIN) that is one of the essential properties of tumor malignancy is associated with abnormal centrosome amplification and disturbed mitotic (M phase) checkpoint control, suggesting that certain centrosomal kinases cause induction of CIN. Furthermore, abnormal cell growth due to inability to enter the G0 phase is another important trait of cancer. In this study, we demonstrate that the centrosomal kinases, Lats1 and Lats2, control the mitotic checkpoint through centrosomal integrity and chromosomal segregation and prevent abnormal cell growth. These results suggest that Lats1/2 kinases comprise a novel signaling pathway which links G0 to M phases of the cell cycle.