Development of Catalytic Synthetic Reactions with High Clark Number Elements (Without A small Amounts of Rare Metals)

高克拉克数元素（不含少量稀有金属）催化合成反应的进展

• 批准号: 22590008
• 负责人: KONDO Kazuhiro
• 金额: $ 3万
• 依托单位: Nagoya City University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2010
• 资助国家: 日本
• 起止时间: 2010 至 2012
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-22590008/
• 关键词: 触媒的合成反応; 有機化学; クラーク数; アリール化; シアノシリル化; ヒドロシリル化; N-複素環カルベン; Duphos; 触媒; 合成化学; N-複素環型カルベン; 遷移金属; 1,2-付加; 触媒的不斉反応; アルデヒド; ニッケル; ホウ素

1) The Ni-catalyzed asymmetric arylation of benzaldehydes bearing an ortho-masked H group with potassium aryltriolborates has been developed. The keys to success were (i) steric tuning of benzaldehyde derivatives bearing an ortho-Me2PhSi group, and (ii) the use of potassium arylborates as aryl sources.2) A method for cyanation reaction of carbonyl and imino compounds with trimethylsilyl cyanide in the presence of N-heterocyclic carbene prepared from 1,3-bis(2,4,6,-trimethylphenyl)imidazolium chloride and potassium tert-butoxide. has been developed.

1)研究了镍催化的邻掩氢苯甲醛与三硼酸芳基钾的不对称芳基化反应。成功的关键是(i)邻位me2phsi基团的苯甲醛衍生物的立体调谐，以及（ii）使用芳基硼酸钾作为芳基源。2)以1,3-二（2,4,6，-三甲基苯基）咪唑氯和叔丁二氧化钾为原料，在n -杂环碳存在下，羰基和亚胺类化合物与三甲基硅氰氰化反应的方法。已经开发出来了。

项目成果

Et-Duphos-Nickel-Catalyzed Asymmetric Arylation of Benzaldehyde Derivatives Bearing an ortho-Me_2PhSi Group with Potassium Aryltriolborate

Et-Duphos-镍催化芳基三醇硼酸钾对带有邻位 Me_2PhSi 基团的苯甲醛衍生物进行不对称芳基化

• 发表时间: 2009
• 期刊: Tetrahedron Lett.
• 作者: Ohno;H.;Tanaka;T.;et al;Fumie Sakurai
• 通讯作者: Fumie Sakurai

Development of asymmetric reactions using catalysts, which are composed of elements of a high Clarke number

使用由高克拉克数元素组成的催化剂开发不对称反应

• 发表时间: 2010
• 作者: W.-H.Cai;K.Matsunami;H.Otsuka;T.Shinzato;Y.Takeda;Kazuhiro Kondo
• 通讯作者: Kazuhiro Kondo

The remarkable solvent effect on Zn(OAc)2-catalyzed hydrosilylation of ketones.

• DOI: 10.1248/cpb.58.989
• 发表时间: 2010-07
• 期刊: Chemical & pharmaceutical bulletin
• 影响因子: 1.7
• 作者: H. Ozasa;K. Kondo;T. Aoyama

Nickel-Catalyzed 1,2-Addition of Potassium Aryltrifluoroborates to α,β-Unsaturated Aldehydes

镍催化芳基三氟硼酸钾与 α,β-不饱和醛的 1,2-加成反应

• 发表时间: 2009
• 期刊: Chem.Pharm.Bull.
• 作者: Y. Uemura;S. Sugimoto;K.Matsunami;H. Otsuka;Y. Takeda;M. Kawahata K. Yamaguchi:;Fumie Sakurai
• 通讯作者: Fumie Sakurai